Publications by authors named "Celmario Castro Brandao"
Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects the synovial fluid of joints, tendons, and some extra-articular sites. Biologic agents have been highly effective and are comparable in reducing RA symptoms, slowing disease progression, and improving physical function; however, concerns have been raised about the risks of several potential adverse effects. Thus, this study aimed to assess the safety of biological therapy in patients with rheumatoid arthritis in observational studies using administrative health databases.
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- The study investigates the effectiveness of biological therapy in treating rheumatoid arthritis (RA) by analyzing data from various health databases and focusing on different types of DMARDs.
- It compares outcomes of tumor necrosis factor inhibitors (TNFi) and non-TNFi drugs, as well as analyzes the effectiveness of biological DMARDs versus Janus kinase inhibitors (JAKi).
- The findings show lower effectiveness of TNFi compared to non-TNFi and bDMARDs compared to JAKi, while adalimumab, etanercept, and golimumab demonstrated better effectiveness than infliximab.
[National primary health care policy in Brazil: an analysis of the review process (2015-2017)Política Nacional de Atención Básica en Brasil: un análisis del proceso de revisión (2015-2017)].
Rev Panam Salud Publica
November 2018
Objective: To describe and discuss events associated with the latest review of the national primary health care (PHC) policy in Brazil (, PNAB) so as to highlight narratives that may contribute to future analyses focusing on the formulation, implementation, and assessment of this policy.
Method: Participant observation report of the PNAB review process, based on content and document analyses.
Results: The review process of PNAB, which took place between 2015 and 2017, was strongly marked by technical and political dispute among the Ministry of Health and authorities representing municipal and state health departments.