Mucocutaneous Findings and Course in an Adult With Zika Virus Infection.

Importance: The Zika virus epidemic has been declared a public health emergency of international concern by the World Health Organization. We describe the mucocutaneous features and histologic correlation in a patient with the acute Zika virus infection.

Observations: We observed the presence of a diffuse papular descending eruption, petechiae on the palate, and hyperemic sclerae in a 44-year-old man returning from Puerto Rico with confirmatory testing for the Zika virus.

Computer-assisted diagnosis of melanoma.

The computer-assisted diagnosis of melanoma is an exciting area of research where imaging techniques are combined with diagnostic algorithms in an attempt to improve detection and outcomes for patients with skin lesions suspicious for malignancy. Once an image has been acquired, it undergoes a processing pathway which includes preprocessing, enhancement, segmentation, feature extraction, feature selection, change detection, and ultimately classification. Practicality for everyday clinical use remains a vital question.

[Abnormal uterine hemorrhage in climacteric. Medical management].

Following a review of the literature, the authors examine the drugs which are currently used to treat anomalous uterine bleeding during menopause, illustrating their aims and justifying the rationale underlying their use. They conclude by stating that a satisfactory treatment often does not exist, but it is the task of the specialist to gauge the level and sequence of treatments in order to achieve the hoped-for result.

[Abnormal uterine hemorrhage in the climacteric. Diagnostic approach].

Having made a detailed list of the invasive and non-invasive diagnostic techniques used to evaluate anomalous uterine bleeding in menopause, the authors conclude by affirming that hysteroscopy undoubtedly represents the most reliable diagnostic technique and that echography should be the preferred first diagnostic step since it allows the adnexa to be examined and is less invasive and cheaper.

[Anomalous uterine hemorrhages in the climacteric. Their etiopathogenesis].

Anomalous uterine bleeding accounts for approximately two-thirds of the causes of outpatient gynecological check-ups for women in menopause. The high incidence of this pathology raises considerable problems from a clinical and social point of view. In this paper the authors outline the main causes of both organic and functional bleeding.

[Menopause. Hormone substitution therapy and prevention of cardiovascular risk].

Background And Aims: Cardiovascular disease is the major cause of death in over 60-year-old women. The mean age of onset is about 10 years later in women compared to men, a difference which can be explained by the end of physiological estrogen production in menopause.

Methods: The authors treated a group of 68 menopausal patients with HRT for a period of 5 years.

[Clinical efficacy of tamoxifen in the treatment of premenstrual mastodynia].

Background: Premenstrual syndrome (PMS), which was first described by Frank in 1931, is a clinical condition that is not easy to classify in terms of either symptoms or from a diagnostic and therapeutic point of view.

Aims: The aim of this study was to evaluate the efficacy of tamoxifen, an antiestrogen drug, using a double-blind study with placebo in the treatment of mastodynia, one of the most frequent symptoms of PMS, given that an absolute or relative increase in estrogens is one of the most controversial etiopathogenetic hypotheses.

Methods: The study included a group of 88 outpatients aged between 22 and 40 with regular menstrual cycles and intense mastodynia.

[Clinical study of the use of a new tri-phasic pill].

The paper reports the results of a study to assess the contraceptive efficacy of a new triphasic pill (Trinovum - Cilag AG). The pill was administered to 50 women aged between 18 and 41 years for 12 months, giving a total of 600 menstrual cycles. Data confirm the value of this pill which ensures excellent contraceptive efficacy and is well tolerated by patients with very few adverse effects.

[Uterine fibromyoma in pregnancy].

Data are reported relating to the study of 100 pregnant women, aged between 30 and 49 years old, effected by one or more fibroma nodules on the body of the womb. From an analysis of results, it appears that appropriate obstetric care can significantly reduce the risk of both maternal and fetal complications.

[Urinary tract infection during pregnancy].

Infections of the urinary tract are particularly frequent in pregnancy (3-10%). Immediate treatment of all symptomatic forms and screening for asymptomatic forms are vital to prevent damage to mother and fetus.

[Effectiveness of povidone-iodine in the treatment of non-specific vaginitis].

Thirty-two cases of aspecific vaginitis treated with a ready-to-use providone-iodine solution are reported. Results were highly positive with regard to the efficacy and safety of the treatment.

[Hormonal contraception using estroprogestins].

Today the estroprogestagen pill is the most valid method of contraception given that its benefits far outweigh its risks. The paper stresses the importance of a thorough anamnestic, clinical and laboratory examination so as to obtain correct and safe steroid contraception. The efficacy and excellent tolerance of the combined method currently make it the most widespread form of oral contraception.

[Perinatal mortality in placental insufficiency].

The review of 55 cases of placental failure and the results obtained reveal a 54% mortality rate.

[Use of orgotein in the treatment of reactive damage to the use of high-energy radiation].

A study has been carried out on 62 patients submitted to pre- and postoperative X-ray treatment, evaluating tolerance and effectiveness of orgotein administered i.m. The therapeutic results obtained may be considered very satisfactory.