Publications by authors named "Celine Vaugier"
Article Synopsis
- The study focused on the role of murine mast cell protease 4 (MCPT4) in kidney injury caused by ischemia reperfusion.
- MCPT4-deficient mice showed worse kidney function and increased inflammation, suffering from more neutrophil infiltration and cell damage compared to normal mice.
- This research suggests that MCPT4 has an anti-inflammatory role by regulating neutrophil behavior, which may help mitigate kidney damage during such injuries.
Renal transplants remain a medical challenge, because the parameters governing allograft outcome are incompletely identified. Here, we investigated the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion injury. In a retrospective cohort study of renal allograft recipients (=169), increased baseline levels of serum ferritin reliably predicted a positive outcome for allografts, particularly in elderly patients.
View Article and Find Full Text PDFIgA plays ambivalent roles in the immune system. The balance between inhibitory and activating responses relies on the multimerization status of IgA and interaction with their cognate receptors. In mucosal sites, secretory IgA (SIgA) protects the host through immune-exclusion mechanisms, but its function in the bloodstream remains unknown.
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