Publications by authors named "Celine Rohrmus"
Acta Neuropathol Commun
May 2023
Article Synopsis
- Glioblastoma (GB) IDH-wildtype is a highly aggressive brain tumor that shows significant resistance to immunotherapy, with the translocator protein 18 kDa (TSPO) playing a key role in this process.*
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- TSPO expression in GB cells correlates with immune infiltration and resistance to T cell-mediated killing, as it regulates apoptosis pathways and is upregulated in response to cytokines from T cells.*
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- Targeting TSPO may enhance the effectiveness of immunotherapy for GB by overcoming intrinsic resistance mechanisms and improving the sensitivity of cancer cells to immune attacks.*
