Publications by authors named "Celine Remigio"
N Engl J Med
September 2021
Article Synopsis
- Zika virus infections can lead to serious complications, but there are currently no approved vaccines available.
- A phase 1 clinical trial tested a synthetic DNA vaccine (GLS-5700) for safety and immune response in 40 participants, using intradermal injections combined with electroporation.
- Results showed no serious adverse effects and a strong immune response, with antibody production indicating potential effectiveness against ZIKV, as proven by protecting mice from infection.
Lancet Infect Dis
September 2019
Article Synopsis
- The study investigated the safety and effectiveness of the GLS-5300 DNA vaccine for MERS in healthy adults aged 18-50.
- Participants received various doses (0.67 mg, 2 mg, and 6 mg) through intramuscular injections, with safety monitored by a committee.
- Results indicated that there were no serious vaccine-related adverse events, although most participants (93%) experienced mild injection-site reactions.
