Publications by authors named "Celine Pillot-Brochet"
Nucleic Acids Res
October 2003
Article Synopsis
- The study investigates how the activation of the ras oncogene (Ha-ras) causes malignant transformation in breast cancer cells using advanced methods to identify altered gene expressions.
- Researchers found 166 genes that are either over- or under-expressed in the MCF7-ras cell line, which play crucial roles in tumor behavior, including growth, apoptosis resistance, and structural changes.
- An integrative model was developed to illustrate the signaling pathway changes, proposing specific intervention points that could selectively induce cell death in Ha-ras-transformed cells, which were later validated through laboratory tests.
