Publications by authors named "Celine Lengelle"
Article Synopsis
- A phase 3 clinical trial investigated if intravenous hydrocortisone could reduce mortality in patients with severe community-acquired pneumonia compared to a placebo.
- The study involved 800 patients, and results showed that those receiving hydrocortisone had a significantly lower death rate (6.2%) at 28 days versus 11.9% in the placebo group.
- Additionally, patients on hydrocortisone required less mechanical ventilation and vasopressors compared to those on placebo, with similar rates of hospital-acquired infections and bleeding risks.
Vascular endothelial growth factor, tissue factor, coagulation and fibrinolysis markers in slow-flow vascular malformations: a prospective study of treatment with sirolimus.
Br J Dermatol
January 2023
Article Synopsis
- Researchers tested whether anakinra, a drug for blocking interleukin-1 receptors, could help moderate COVID-19 patients requiring oxygen treatment.
- In a trial with 71 enrolled patients, those receiving anakinra had lower treatment success and higher mortality at 28 days compared to those receiving standard care.
- The study concluded that anakinra was not effective and even proved to be worse than standard care for treating moderate COVID-19 pneumonia.
Introduction: Gabapentinoids are ligands of the α2-δ subunit of voltage-gated calcium channels (Cav) that have been associated with a risk of peripheral edema and acute heart failure in connection with a potentially dual mechanism, vascular and cardiac.
Objectives & Methods: All cases of peripheral edema or heart failure involving gabapentin or pregabalin reported to the French Pharmacovigilance Centers between January 1, 1994 and April 30, 2020 were included to describe their onset patterns (e.g.
Importance: Sirolimus is increasingly being used to treat various vascular anomalies, although evidence of its efficacy is lacking.
Objective: To assess the efficacy and safety of sirolimus for children with slow-flow vascular malformations to better delineate the indications for treatment.
Design, Setting And Participants: This multicenter, open-label, observational-phase randomized clinical trial included 59 children aged 6 to 18 years with a slow-flow vascular malformation who were recruited between September 28, 2015, and March 22, 2018, in 11 French tertiary hospital centers.
Many drugs are responsible, through different mechanisms, for peripheral oedema. Severity is highly variable, ranging from slight oedema of the lower limbs to anasarca pictures as in the capillary leak syndrome. Although most often noninflammatory and bilateral, some drugs are associated with peripheral oedema that is readily erythematous (eg, pemetrexed) or unilateral (eg, sirolimus).
View Article and Find Full Text PDFImportance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.
Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.
Article Synopsis
- Alitretinoin, a retinoid for severe hand eczema, has a similar side effect profile to isotretinoin but shows a higher incidence of serious psychiatric disorders.
- In a study analyzing adverse drug reactions (ADRs) from 2012 to 2016, 52 serious and 88 non-serious unexpected ADRs were reported, including new cases like myocardial infarction and pancreatitis.
- Due to these findings, particularly the significant rate of psychiatric issues and pregnancy exposures, the French National Agency for Medicines has restricted initial prescriptions of alitretinoin.