Publications by authors named "Celine Gonfroy-Leymarie"
Article Synopsis
- The study aimed to determine if diabetes is a risk factor for severe COVID-19 outcomes, independent of age and other health conditions, as diabetes is often seen in older individuals.
- Conducted as part of the CORONADO initiative, the research matched 2210 COVID-19 patients with and without diabetes by age, sex, and admission date, assessing outcomes like death and the need for invasive mechanical ventilation.
- Results showed that diabetes patients had higher rates of adverse outcomes within both 7 and 28 days of hospital admission, indicating that diabetes is a significant risk factor for severe COVID-19 complications regardless of age and comorbidity.
Context: In men with congenital hypogonadotropic hypogonadism (CHH), gonadotropin deficiency and testicular impairment exist since fetal development and persist throughout life. In a few reported cases of acquired HH (AHH), HH onset occurs mainly post pubertally.
Objective: This work aimed to compare the natural history and reproductive status in large series of CHH and lesional AHH evaluated in a single expert academic center.
Article Synopsis
- This study examined how having metabolic and bariatric surgery (MBS) affects the outcomes of patients with type 2 diabetes (T2D) and severe obesity who are hospitalized for COVID-19.
- Researchers matched patients with a history of MBS to those without, focusing on their age, sex, and BMI at the time of either surgery or COVID-19 admission.
- Results showed that patients with MBS had significantly lower rates of invasive mechanical ventilation or death within 7 and 28 days following admission compared to those without MBS, suggesting better COVID-19 prognosis for MBS patients.
Article Synopsis
- The study examined sex differences in severe outcomes of COVID-19 among adults with diabetes, analyzing data from 2,380 hospitalized patients.
- Findings revealed that females had a lower risk of invasive mechanical ventilation, death, and ICU admission compared to males, although this female advantage was less evident in overall in-hospital mortality.
- The research highlighted specific predictors of death linked to sex, emphasizing the need for tailored COVID-19 management strategies based on biological differences.
Article Synopsis
- The study focuses on identifying β-cell epitopes recognized by CD8(+) T cells in type 1 diabetes (T1D) patients, specifically those linked to the HLA-B7 molecule, which offers some protection against T1D.
- Using techniques like DNA immunization and predictive algorithms, researchers identified candidate epitopes from GAD and preproinsulin that were mainly recognized by new-onset T1D patients, distinguishing them from type 2 diabetes and healthy individuals.
- Findings indicate that HLA-B7-restricted epitopes exhibit unique characteristics, such as weak binding and stability compared to HLA-A2, and reveal different immune responses in T1D children versus adults, which may clarify the protective effects of