17beta-estradiol deficiency reduces potassium excretion in an angiotensin type 1 receptor-dependent manner.

This study examined the effects of ovariectomy (OVX) and 17beta-estradiol (E(2)) replacement (OVX + E(2)) on renal function in Sprague-Dawley rats. OVX caused a 40% decrease in the fractional excretion of potassium (FE(K(+))) that was prevented by E(2) replacement [Sham, 24.2 +/- 2.

Translational control of the rat angiotensin type 1a receptor by alternative splicing.

The rat angiotensin type 1a receptor (AT1aR) is comprised of three exons. Two transcripts are possible due to alternative splicing of exon 2 (E1,3 and E1,2,3). Both transcripts code for identical AT1aR proteins since they differ only in the length of their 5' leader sequence (5'LS).

Central AII evokes a normal sodium appetite in the Fischer rat, but its low spontaneous sodium intake may be related to reduced excitation and increased inhibition in septo-preoptic AII neurons.

Fischer rats show a low or absent basal salt appetite and a reduced intake of salt solutions in response to peripherally administered angiotensin II (AII) when compared to other strains. We investigated spontaneous sodium intake, and sodium intake after intracerebroventricular (i.c.