Publications by authors named "Celine Clauss"
Article Synopsis
- The nucleocapsid protein (NC) of HIV-1 contains CCHC zinc fingers necessary for viral DNA synthesis and works as a nucleic acid chaperone.
- NC facilitates the first DNA strand transfer by binding to cTAR DNA, destabilizing its structure, and promoting the correct pairing with TAR RNA.
- Research using NC mutants reveals that the proper arrangement of zinc fingers and specific hydrophobic residues is critical for effective cTAR binding, destabilization, and inhibition of self-priming during DNA synthesis.
