Publications by authors named "Celine Arbizu"

Purpose: Information and communication technologies are crucial for social and professional integration, but access to technology can be difficult for people with physical impairments. Text entry can be slow and tiring. We developed a free and open-source module called for use with AAC (augmentative/alternative communication) software in French language.

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Article Synopsis
  • Primary progressive aphasias (PPA) lack consistent language tests for diagnosis and follow-up, prompting the development of a new rapid test, "PARIS," aimed at improving reliability.
  • The "PARIS" test showed 88% inter-rater consistency and effectively distinguished PPA from typical Alzheimer's disease (AD), while also identifying two common PPA variants—semantic and logopenic.
  • With a quick application time of about 10 minutes, the "PARIS" test demonstrated high sensitivity for detecting language decline, making it a promising tool for diagnosis and therapeutic research in neurodegenerative diseases impacting language.
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Objectives: The outcome of aphasia at 3 months is variable in patients with moderate/severe stroke. The aim was to predict 3-month aphasia outcome using prediction models including initial severity in addition to the interaction between lesion size and location at the acute phase.

Methods: Patients with post-stroke aphasia (assessed by the Aphasia Rapid Test at day 7-ART D7) and MRI performed at day 1 were enrolled (n = 73).

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Objectives: To identify the critical brain regions associated with 7-days, 3 and 6-months aphasia severity using diffusion-weighted imaging (DWI) in acute post-stroke patients.

Materials And Methods: We performed a voxel-based ADC (Apparent Diffusion Coefficient) analysis to identify the critical brain areas correlated with aphasia at the acute (7-days outcome) and chronic stages (3 and 6-months). The location of these areas was compared with the trajectory of the dorsal (the arcuate fasciculus) and the ventral language pathways (the inferior fronto-occipital and the uncinate fasciculi).

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Article Synopsis
  • The study aimed to analyze the effects of repetitive sessions of transcranial direct current stimulation (tDCS) on naming abilities in individuals with post-stroke aphasia, addressing previous meta-analyses that showed no effect when data from varying session types were combined.
  • Researchers conducted a meta-analysis using individual patient data, examining seven studies with 68 post-stroke patients; results indicated that tDCS significantly improved naming abilities (35% improvement) compared to a sham treatment (25% improvement).
  • Findings suggested a dose-dependent benefit, showing that more than five tDCS sessions led to better outcomes, with effectiveness independent of aphasia severity, comprehension issues, or the time elapsed since the
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Background: The contribution of lesion size and location in poststroke aphasia is debated, especially the extent to which aphasia severity is affected by damage to specific white matter areas.

Objective: To identify specific white matter areas critical for poststroke aphasia global severity and to determine whether injury to these areas had more impact on aphasia severity than the infarct volume.

Methods: Twenty-three chronic poststroke aphasic patients were assessed with the Aphasia Rapid Test (ART) and the Boston Diagnosis Aphasia Examination (BDAE) global severity scales and underwent diffusion tensor and structural imaging.

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Background And Objectives: Motor neglect (MN) is a clinically important condition whereby patients with unilateral brain lesions fail to move their contralateral limbs, despite normal muscle strength, reflexes, and sensation. MN has been associated with various lesion sites, including the parietal and frontal cortex, the internal capsule, the lenticulostriate nuclei, and the thalamus. In the present study, we explored the hypothesis that MN depends on a dysfunction of the medial motor system by performing a detailed anatomical analysis in four patients with MN.

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