Pegylated-l-asparaginase therapy for feline large cell lymphoma: 82 cases (2017-2020).

Objectives: The present study aimed to investigate pegylated-l-asparaginase monotherapy for feline large cell lymphoma as a potential alternative to palliative corticosteroids treatment in animals whose owners declined cytotoxic chemotherapy.

Methods: A retrospective, descriptive case series of cats treated initially with pegylated-l-asparaginase as a sole therapy for feline large cell lymphoma is reported. The treatment protocol consisted of 12 intramuscular injections of pegylated-l-asparaginase with increasing intervals.

External validation of a United Kingdom primary-care Cushing's prediction tool in a population of referred Dutch dogs.

Background: A prediction tool was developed and internally validated to aid the diagnosis of Cushing's syndrome in dogs attending UK primary-care practices. External validation is an important part of model validation to assess model performance when used in different populations.

Objectives: To assess the original prediction model's transportability, applicability, and diagnostic performance in a secondary-care practice in the Netherlands.