Publications by authors named "Celina Y Jones"
Article Synopsis
- Understanding how cancer starts and grows is super important for making better treatments!*
- Scientists have found changes in certain genes that make histones (proteins that help pack DNA) become "oncohistones" which can lead to cancer.*
- Yeast is a helpful model for studying these proteins because they have simpler genetics but similar proteins to humans, allowing researchers to discover how these mutations work and find new ways to treat cancer.*
Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that mutations that convert histone H3 amino acid 50 from a glutamate to a lysine (H3E50K) support an oncogenic phenotype in human cells. Expression of H3E50K is sufficient to transform human cells as evidenced by a dramatic increase in cell migration and invasion, and a statistically significant increase in proliferation and clonogenicity.
View Article and Find Full Text PDFTelomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). Currently, the primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats (cECTRs).
View Article and Find Full Text PDFTelomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). The primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats (cECTRs).
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