A phosphorylation code coordinating transcription condensate dynamics with DNA replication.

Chromatin is organized into compartments enriched with functionally-related proteins driving non-linear biochemical activities. Some compartments, transcription foci, behave as liquid condensates. While the principles governing the enrichment of proteins within condensates are being elucidated, mechanisms that coordinate condensate dynamics with other nuclear processes like DNA replication have not been identified.

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. In the first of several approaches, a biological signal sequence trap in yeast cells was utilized to identify cDNA clones encoding putative secreted proteins. A second strategy utilized various algorithms that recognize features such as the hydrophobic properties of signal sequences to identify putative proteins encoded by expressed sequence tags (ESTs) from human cDNA libraries.

[Effects of iron-deficiency anemia on placenta and birth weight].

Objective: To determine placenta alterations in iron deficiency anemia cases and the effect of this condition on birthweight.

Patients, Material And Methods: One hundred and fifty three women with term-pregnancy and their newborns were included. Patients with iron deficiency anemia were those with an hemoglobin of less than 11.