Publications by authors named "Celie Cokelaere"
Purpose: Uterine serous carcinoma (USC) is generally associated with poor prognosis due to a high recurrence rate and frequent treatment resistance; hence, there is a need for improved therapeutic strategies. Molecular analysis of USC identified several molecular markers, useful to improve current treatments or identify new druggable targets. PPP2R1A, encoding the Aα subunit of the tumor suppressive Ser/Thr phosphatase PP2A, is mutated in up to 40% of USCs.
View Article and Find Full Text PDFPurpose: TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6 - all pleiotropic modulators of the DNA Damage Response (DDR). Here, we investigated the role of TIPRL1 in the radiotherapy (RT) response of Head and Neck Squamous Cell Carcinoma (HNSCC).
Methods: TIPRL1 mRNA (cBioportal) and protein expression (immunohistochemistry) in HNSCC samples were linked with clinical patient data.
Article Synopsis
- The study investigates fast feedback mechanisms during sprouting angiogenesis using a combination of selective plane illumination microscopy (SPIM) and customized image analysis techniques.
- SPIM allows for high-resolution imaging of large volumes, enabling the observation of subcellular activities and matrix deformations in a multicellular environment at very high temporal resolution.
- Findings indicate that adjacent sprouting cells exhibit collective yet non-synchronized activity, with notable relationships between the dynamics of cellular protrusions and surrounding matrix changes.