Publications by authors named "Celia K Tran"
Article Synopsis
- The study aimed to explore the circadian rhythms in the trigeminal ganglion of mice, which are relevant to understanding headache disorders like migraines and cluster headaches.
- Researchers used a combination of ex vivo and single-cell cultures, along with behavioral and genetic analyses, to assess the influences of these rhythms on pain sensitivity in a nitroglycerin-induced headache model.
- Results revealed significant circadian patterns in gene expression and pain sensitivity, including the identification of potential gene targets for therapies that align with these rhythms.
Background And Objectives: Cluster headache and migraine have circadian features at multiple levels (cellular, systems, and behavioral). A thorough understanding of their circadian features informs their pathophysiologies.
Methods: A librarian created search criteria in MEDLINE Ovid, Embase, PsycINFO, Web of Science, and Cochrane Library.
Numerous molecular and physiological processes in the skeletal muscle undergo circadian time-dependent oscillations in accordance with daily activity/rest cycles. The circadian regulatory mechanisms underlying these cyclic processes, especially at the post-transcriptional level, are not well defined. Previously, we reported that the circadian E3 ligase FBXL21 mediates rhythmic degradation of the sarcomere protein TCAP in conjunction with GSK-3β, and Psttm mice harboring an Fbxl21 hypomorph allele show reduced muscle fiber diameter and impaired muscle function.
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