A Novel Neuron-Specific Regulator of the V-ATPase in .

The V-ATPase is a highly conserved enzymatic complex that ensures appropriate levels of organelle acidification in virtually all eukaryotic cells. While the general mechanisms of this proton pump have been well studied, little is known about the specific regulations of neuronal V-ATPase. Here, we studied CG31030, a previously uncharacterized protein predicted from its sequence homology to be part of the V-ATPase family.