Publications by authors named "Celestino Bufarini"

to research retrospectively the efficacy of Erenumab's treatment, thus allowing to describe a summary more in line with the reality observed every day in clinical practice, relative to a sample of patients widely heterogeneous. The study aims to confirm the efficacy of Erenumab, in terms of reduction of migraine days per month, from baseline to month 12 of treatment. Additional objectives included a reduction in the number of days of symptomatic drug use and change from baseline in the Migraine Disability Assessment Score Questionnaire (MIDAS); Methods: the analysis included all patients treated for 12 months with Erenumab during the year 2019-2020.

View Article and Find Full Text PDF

Objectives: To design and execute a comprehensive microbiological validation protocol to assess a brand-new sterile compounding robot in a hospital pharmacy environment, according to ISO and EU GMP standards.

Methods: Qualification of the Class-A inner environment of the robot was performed through microbial air and surface quality assessment utilising contact plates, swabs and particulate matter monitoring. To evaluate the effectiveness of the microbial decontamination process (UV rays) challenge test against , , spores and was used.

View Article and Find Full Text PDF

In 2005, the Pharmacy Department of the University Hospital of Ancona began collaboration with the engineers of the Loccioni group in order to realize a fully automated system for the preparation of cytostatic drugs, which could be safe for both healthcare workers and patients. At present, the cytotoxic laboratory of Ancona is equipped with two robots and one Class II biological-safety cabinet. The introduction of the robots in the cytotoxic laboratory has increased both efficiency and safety of the working process.

View Article and Find Full Text PDF

Since 2007, the preparation of cancer drugs at the Pharmacy of the University Hospital of Ancona has been progressively robotized. Currently, the process of preparation of intravenous cancer drugs is almost totally automated (95%). At present, the Cytotoxic laboratory of Ancona is the sole, in Europe, that can count on two robots.

View Article and Find Full Text PDF