Synergism of in vitro plasmodicidal activity of phospholipase A2 isoforms isolated from panamanian Bothrops asper venom.

Bothrops asper is one of the most important snake species in Central America, mainly because of its medical importance in countries like Ecuador, Panama and Costa Rica, where this species causes a high number of snakebite accidents. Several basic phospholipases A (PLAs) have been previously characterized from B. asper venom, but few studies have been carried out with its acidic isoforms.

Antimalarial activity of basic phospholipases A isolated from Paraguayan Bothrops diporus venom against Plasmodium falciparum.

Malaria is a parasitic infectious disease and was responsible for 400.000 deaths in 2018. represents the species that causes most human deaths due to severe malaria.

First Molecular Report of () and () in Paraguayan Inhabitants Using High-Resolution Melt-PCR.

American tegumentary leishmaniasis is an endemic anthropozoonosis undergoing expansion on the American continent. The disease is caused by several species and it is manifested as cutaneous and mucocutaneous leishmaniasis. In this study, we evaluate the viability of high-resolution melt polymerase chain reaction (HRM-PCR) analysis to differentiate four closely related species as a routine tool for the diagnosis of leishmaniasis.

Antiparasitic effect of the Psidium guajava L. (guava) and Psidium brownianum MART. EX DC. (araçá-de-veado) extracts.

In the search for new therapeutic agents against neglected diseases, both aqueous and hydroethanolic extracts from Psidium guajava L. and P. brownianum Mart ex DC leaves were investigated regarding their antiparasitic effect and cytotoxic potential.

BmajPLA-II, a basic Lys49-phospholipase A homologue from Bothrops marajoensis snake venom with parasiticidal potential.

Snake venoms contain various proteins, especially phospholipases A (PLAs), which present potential applications in diverse areas of health and medicine. In this study, a new basic PLA from Bothrops marajoensis with parasiticidal activity was purified and characterized biochemically and biologically. B.

The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells.

Ethnopharmacological Relevance: Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections.

Aim Of The Study: The objective of the study was to determine the composition of venoms obtained from three different Paraguayan Rhinella species, to establish the constituents of a preparation sold in the capital city of Paraguay to treat cancer as containing the toad as ingredient, to establish the effect of the most active Rhinella schneideri venom on the cell cycle using human breast cancer cells and to assess the antiprotozoal activity of the venoms.

Methods: The venom obtained from the toads parotid glands was analyzed by HPLC-MS-MS.

Phenolic composition and antiparasitic activity of plants from the Brazilian Northeast "Cerrado".

This work describes the antiparasitic and cytotoxic activities of three plant species from the Cerrado biome, Northeastern Brazil. Significant antiparasitic inhibition was observed against Trypanosoma cruzi (63.86%), Leishmania brasiliensis (92.

Zanthoxylum chiloperone leaves extract: first sustainable Chagas disease treatment.

Ethnopharmacological Relevance: Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) stem bark is used traditionally in Paraguay for its antiparasitic properties.