Publications by authors named "Celena M Josephitis"
Article Synopsis
- SAR studies are essential for drug and agrochemical development but often lack synthetic strategies for nitrogen heteroaromatics found in small molecule candidates.
- An innovative method is introduced where pyrimidine-containing compounds are transformed into N-arylpyrimidinium salts, which can be cleaved into a three-carbon iminoenamine building block, facilitating various heterocycle-forming reactions.
- This deconstruction-reconstruction strategy enhances the diversity of heterocycles obtainable from pyrimidine cores and may be applicable to other heterocycle classes in the future.
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread components of pharmaceuticals. Their occurrence derives from a suite of physiochemical properties that match key criteria in drug design and is tunable by varying their substituents. Developments in synthetic chemistry, therefore, directly impact these efforts, and methods that can install various groups from azine C-H bonds are particularly valuable.
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