Publications by authors named "Cees Schaar"
Background: Progressive multifocal leukoencephalopathy (PML) is a rare infectious cause of sub-acute neurological symptoms, and occurs predominantly in immunocompromised patients. PML is caused by reactivation of the JC virus.
Case Description: A 79-year-old man with a history of chronic B-cell lymphatic leukaemia (B-CLL) presented at our hospital with a neurological deficit of the left side of his body.
Role of eHealth application Oncokompas in supporting self-management of symptoms and health-related quality of life in cancer survivors: a randomised, controlled trial.
Lancet Oncol
January 2020
Article Synopsis
- A study was conducted to evaluate the effectiveness and use of Oncokompas, a web-based eHealth tool designed to help cancer survivors manage their health independently by tracking their quality of life and symptoms.
- The trial involved 625 cancer survivors from 14 hospitals in the Netherlands, who were randomly assigned to either use Oncokompas immediately or after a 6-month delay, with assessments of patient activation conducted at multiple intervals.
- Results showed no significant differences in patient activation between the two groups over the follow-up period, indicating that the intervention might not have had the intended impact on self-management skills.
Objectives: Assessment of "real-world" treatment strategies and outcome in Dutch polycythemia vera (PV) patients.
Methods: Retrospective chart review in 150 patients with PV (WHO 2008 diagnostic criteria) from 10 major non-academic hospitals in the Netherlands.
Results: Patients (median age 64 years, 49% male) frequently had cardiovascular risk factors (56%) and prior vascular events (31%).
Aim: The aim of this systematic review is to summarise all available data on the effect of a geriatric evaluation on the multidisciplinary treatment of older cancer patients, focussing on oncologic treatment decisions and the implementation of non-oncologic interventions.
Methods: A systematic search in MEDLINE and EMBASE for studies on the effect of a geriatric evaluation on oncologic and non-oncologic treatment for older cancer patients.
Results: Literature search identified 1654 reports (624 from Medline and 1030 from Embase), of which 10 studies were included in the review.
Unlabelled: This study assesses whether new treatment strategies developed in clinical trials translate into improved survival for multiple myeloma (MM) patients in the Netherlands. All patients diagnosed with MM in the Northern part of the Netherlands between 1989 and 2005 were retrieved from two regional population-based cancer registries. Information on study participation was derived from linkage with trial information systems.
View Article and Find Full Text PDFProspective studies on the risk of malignant transformation in patients with monoclonal gammopathy of undetermined significance (MGUS) and factors predictive of survival are lacking. The Dutch Comprehensive Cancer Centre West, comprising 1.6 million inhabitants, initiated a prospective hospital-based cohort study on 1464 patients with newly diagnosed M-proteinaemia, median age 73 (17-103) years.
View Article and Find Full Text PDFSerum syndecan-1 was investigated in 189 patients with newly diagnosed monoclonal proteinemia [the diagnoses were multiple myeloma (66), monoclonal gammopathies of undetermined significance (MGUS; n=54), provisional MGUS (no bone marrow examination performed; n=69)] and 36 controls. Syndecan-1 levels ranged widely between all diagnostic categories and were of limited discriminatory value (sensitivity 68%, specificity 78%) in patients with newly diagnosed monoclonal proteinemia.
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