Publications by authors named "Cedric Wilden"
Article Synopsis
- Clinical islet transplantation faces challenges due to cell death caused by ischemia, which may be influenced by the AIM2 inflammasome reacting to abnormal self-dsDNA.
- Research using wild type and AIM2-deficient islets showed that while both types had similar viability under ischemic conditions, AIM2-deficient islets had increased IFN-β and IFN-γ levels, leading to reduced insulin production.
- Ultimately, AIM2 plays a vital role in the success of islet grafts in transplantation by modulating IFN signaling, affecting both revascularization and the ability to regulate blood glucose in diabetic models.
