Publications by authors named "Cedric Stoll"
Therapy with pegylated interferon alpha (pegIFNα) can induce a deep molecular response in a subset of patients with myeloproliferative neoplasms (MPN). Here we investigated the role of Socs2, a negative regulator of cytokine signaling, in modulating the response to pegIFNα in a JAK2-V617F mouse model of MPN. Deleting Socs2 in JAK2-V617F mice resulted in increased sensitivity to cytokines, without causing significant alterations in the MPN phenotype.
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- JAK2-V617F is a common mutation linked to myeloproliferative neoplasms (MPNs) and is also present in some healthy individuals with a condition called clonal hematopoiesis of indeterminate potential (CHIP).
- The study investigated how interleukin-1β (IL-1β)-mediated inflammation might influence the progression from JAK2-V617F CHIP to MPNs, using bone marrow transplant experiments in mice.
- Findings showed that the absence of IL-1β reduced the growth and expansion of JAK2-mutant stem cells and suggested that targeting IL-1β could be a strategy to prevent the development of MPNs.
Article Synopsis
- * Research shows that higher IL-1β levels in patients with MPN are associated with the presence of a specific mutant allele (JAK2-V617F), particularly in hematopoietic cells.
- * In mice with this mutation, reducing IL-1β levels leads to decreased inflammation and related bone marrow conditions, suggesting that targeting IL-1β could improve treatments for myelofibrosis, especially when paired with the drug ruxolitinib.
Personality traits are considered as an important aspect in the assessment of child sex offenders (CSOs). The current study sought to elucidate the association between neuroticism, psychopathy, and abusive behavior in low risk CSOs. 43 pedophilic CSOs and 21 controls (CTLs) completed the NEO-Personality Inventory-Revised (NEO-PI-R), Psychopathy Checklist: Screening Version (PCL:SV), and Multiphasic Sex Inventory (MSI).
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