Publications by authors named "Cedric Schweitzer"
Article Synopsis
- The study investigated the link between air pollution and cataract surgery incidence in older adults in Bordeaux, France.
- Researchers followed 829 participants aged 65 and older from 1999-2017, monitoring their cataract surgeries and estimating their long-term air pollution exposure.
- Results showed that long-term exposure to nitrogen dioxide (NO) at levels ≥40 μg/m was significantly associated with increased incidence of cataract surgery, suggesting that meeting air quality standards could benefit public health.
Purpose: Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.
View Article and Find Full Text PDFObjective: To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness.
Methods: The Alienor study, a prospective population-based cohort (Bordeaux, France), includes 963 individuals aged 73 years or older at baseline. The present study included 646 participants with complete RNFL measurement and vitamins.
Introduction: Even though the local tolerance of prostaglandin (PG) analogues has improved drastically since the introduction of preservative-free (PF) eye drops, prescription patterns still vary widely among practitioners and between countries and could have an impact on the ocular surface of treated patients and, in consequence, their adherence. The aim of this study is to explore the prescribing patterns of PG analogues monotherapy in France and to evaluate their impact on ocular surface status.
Methods: This was a national multicenter cross-sectional observational study that was conducted by 18 glaucoma experts in France.
Background/aims: The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe.
View Article and Find Full Text PDFIntroduction: We explored the longitudinal relationship between retinal vascular features and dementia incidence over 10 years.
Methods: Among 584 participants from the Three-City-Alienor (3C-Alienor) population-based cohort, quantitative retinal vascular features (caliber, tortuosity, fractal dimension) were measured using semi-automated software. Dementia was actively diagnosed over the follow-up period.
Rationale: Nd:YAG (neodymium:yttrium-aluminum-garnet) capsulotomy (Nd:YAG-caps) is the gold standard for the treatment of PCO (Posterior Capsule Opacification). There is a lack of real-world data about Nd:YAG-caps use.
Purpose: This study's objectives were to estimate Nd:YAG-caps incidence in France, to describe the patient characteristics, and to analyze the time between surgeries and capsulotomies.
Article Synopsis
- The purpose of the study was to compare the safety and effectiveness of a fixed-dose combination of netarsudil and latanoprost (NET/LAT) with bimatoprost and timolol (BIM/TIM) in treating open-angle glaucoma and ocular hypertension.
- Conducted as a six-month randomized study, participants over 18 years with uncontrolled intraocular pressure were assigned to either NET/LAT or BIM/TIM, with efficacy and safety monitored over the period.
- Results showed that NET/LAT was non-inferior to BIM/TIM, maintaining a similar intraocular pressure at various time points, with both treatments demonstrating comparable safety profiles.
Given the anatomical and functional similarities between the retina and the brain, the retina could be a "window" for viewing brain structures. We investigated the association between retinal nerve fiber layers (peripapillary retinal nerve fiber layer, ppRNFL; macular ganglion cell-inner plexiform layer, GC-IPL; and macular ganglion cell complex, GCC), and brain magnetic resonance imaging (MRI) parameters in young health adults. We included 857 students (mean age: 23.
View Article and Find Full Text PDFChronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, characterized by progressive thinning of the retinal nerve fiber layer (RNFL). We investigated the relationship of air pollution exposure with longitudinal changes of RNFL thickness in the Alienor study, a population-based cohort of residents of Bordeaux, France, aged 75 years or more.
View Article and Find Full Text PDFImportance: The efficacy and safety of femtosecond laser-assisted cataract surgery is well documented. An important requirement for decision makers is the evaluation of the cost-effectiveness of femtosecond laser-assisted cataract surgery (FLACS) over a sufficiently long horizon. Evaluating the cost-effectiveness of this treatment was a preplanned secondary objective of the Economic Evaluation of Femtosecond Laser Assisted Cataract Surgery (FEMCAT) trial.
View Article and Find Full Text PDFPurpose: To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population.
Design: Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium.
Participants: The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants.
Femtosecond laser-assisted cataract surgery: Update and perspectives.
Front Med (Lausanne)
March 2023
Cataract surgery is among the most frequently performed surgical procedures worldwide and has a tremendous impact on patients' quality of life. Phacoemulsification (PCS) is accepted as a standard of care; its technique has continuously evolved and already achieved good anatomical, visual, and refractive outcomes. Lasers in ophthalmology are widely used in clinical practice, femtosecond lasers (FSLs) for corneal surgery in particular.
View Article and Find Full Text PDFPurpose: The purpose of this study was to compare 24-hour intraocular pressure (IOP) related fluctuations monitoring between 2 groups of visual field progression rates in patients with open angle glaucoma (OAG).
Methods: Cross-sectional study performed at Bordeaux University Hospital. Twenty-four-hour monitoring was performed using a contact lens sensor (CLS; Triggerfish; SENSIMED, Etagnières, Switzerland).
Purpose: To estimate the incidence and assess the risk factors associated with 3 adverse events (AEs) after neodymium:yttrium-aluminum-garnet posterior capsulotomy (Nd:YAG-caps): ocular hypertension (OHT), macular edema (ME), and retinal detachment (RD).
Design: Observational cohort study using a nationwide claims database.
Participants: Adults who underwent Nd:YAG-caps between 2014 and 2017, with no ocular disease history in the year before.
Prescribed anti-glaucoma medication consumption and road traffic crash.
Pharmacoepidemiol Drug Saf
May 2023
Background: Glaucoma is one of the leading causes of visual impairment worldwide. Influence of visual defects associated with this condition, as well as potential side effects of anti-glaucoma medications on driving may be a relevant traffic safety concern. This study therefore aimed to investigate whether and/or to what extent prescribed anti-glaucoma medicine consumption is associated with increased likelihood of crash risk, and traffic crash responsibility among drivers involved in road traffic crashes.
View Article and Find Full Text PDFPurpose: To investigate the cost utility of STN1013001, a latanoprost cationic emulsion, versus Latanoprost in patients with open-angle glaucoma or ocular hypertension (OAG/OHT) and concomitant ocular surface disease (OSD) in France.
Methods: An early Markov model, including 7 health states and a 1-year cycle length, was developed to estimate the cost utility of STN1013001 versus Latanoprost from the French health system perspective over a 5-year time horizon. The model was populated with pooled data (treatment adherence, quality of life, disease progression, and resource utilization) collected, via a questionnaire, from a convenience sample of 5 French glaucoma specialists.
Article Synopsis
- The study aimed to analyze the clinical and virological characteristics of patients with herpes simplex keratitis (HSK) caused by acyclovir-resistant herpes simplex virus type 1 (HSV-1).
- Researchers confirmed resistance through gene sequencing and gathered data on HSK episodes, ocular findings, immune status, antiviral treatments, and resistance profiles from 18 patients (average age 67).
- Results indicated that resistance mutations were common, especially in patients with long-standing disease and frequent recurrences, highlighting the need for vigilance in treatment plans, particularly for immunocompromised individuals.
Objective: To investigate the cost-effectiveness of implementing iStent inject trabecular bypass stent (TBS) in conjunction with cataract surgery (Cat Sx) in patients with mild-to-moderate glaucoma from a societal perspective in France. The secondary objective was to explore the economic impact of iStent inject TBS in patients who comply to different degrees with their anti-glaucoma medications.
Methods: A previously published Markov model was adapted to estimate the cost-effectiveness of treatment with iStent inject TBS + Cat Sx versus Cat Sx alone over a lifetime time horizon in patients with mild-to-moderate open-angle glaucoma in France.
Purpose: To evaluate intraoperative intraocular lens (IOL) delivery time and total surgical case time using the UltraSert preloaded delivery system (System U) during routine cataract surgeries and to compare with the manually loaded Monarch delivery system (System M). Physician satisfaction with System U was also assessed.
Patients And Methods: In this prospective observational study, subjects ≥18 years old underwent cataract surgery in 1 eye and received the AcrySof IQ IOL via the manually loaded System M (n=103) or the AcrySof IQ IOL model AU00T0 via the preloaded System U (n=93).
Background: Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear.
Objective: We investigated the factors associated with GLOS in a cohort of patients presenting with acute neurological deficits.
Purpose: To determine the incidence, progression rate, and risk factors for epiretinal membranes (ERMs) in a population of French elderly subjects.
Methods: Seven hundred and thirty-five eyes of 413 participants of the population-based ALIENOR study were included between 2009 and 2010. Participants were re-evaluated every 2 years between 2011 and 2017 (i.
Article Synopsis
- The study investigates the prevalence of epiretinal membranes (ERMs) in elderly French subjects using both standard retinal colour images and spectral-domain optical coherence tomography (SD-OCT).
- A total of 624 participants aged 75 and older were examined, revealing that SD-OCT detected a significantly higher percentage of ERMs compared to colour photographs (52.8% vs. 11.6%).
- The findings suggest that SD-OCT is much more sensitive and should be preferred over colour images for ERM assessment, especially in the early stages of the disease in epidemiological studies.