Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells.

The bone is the third most common site of cancer metastasis. To invade the bone, tumor cells produce osteoclast-activating factors that increase bone resorption by osteoclasts. Here we report that human neuroblastoma cells that form osteolytic lesions in vivo do not produce osteoclast-activating factors but rather stimulate osteoclast activity in the presence of human bone marrow mesenchymal stem cells.

Sandblasted and acid-etched dental implants: a histologic study in rats.

Purpose: Current literature has revealed that surface etching of endosseous implants can improve bone-implant contact. The aim of this study was to evaluate the differences in bone-implant contact (BIC) between sandblasted/acid-etched and machined-surface implants.

Materials And Methods: Thirty-two Sprague-Dawley rats were used in this study.