Clinical and Prognostic Factors in Patients with IgG4-Related Kidney Disease.

Background: IgG4-related kidney disease is a major manifestation of IgG4-related disease, a systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with IgG4-related kidney disease are insufficiently defined.

Methods: We conducted an observational cohort study using data from 35 sites in two European countries.

Symptomatic aortitis at giant cell arteritis diagnosis: a prognostic factor of aortic event.

Background: Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications, and no predictive factor has been identified so far. The aim of this study was to investigate factors associated with the risk of aortic complications in a cohort of GCA aortitis.

Bone marrow biopsy diagnostic yield in internal medicine.

Background: Trephine bone marrow biopsy (BMB) in internal medicine has only been studied in fever of unknown origin and inflammation of unknown origin. The aim was to assess BMB diagnostic yield according to main indications and patient characteristics in internal medicine. Quality of BMB and contribution of bone marrow aspiration (BMA) to BMB were also analyzed.

Temporal Arteritis Revealing Antineutrophil Cytoplasmic Antibody-Associated Vasculitides: A Case-Control Study.

Objective: Temporal arteritis (TA) is a typical manifestation of giant cell arteritis (GCA). Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are rarely revealed by TA manifestations, leading to a risk of misdiagnosis of GCA and inappropriate treatments. This study was undertaken to describe the clinical, biologic, and histologic presentations and outcomes in cases of TA revealing AAV (TA-AAV) compared to controls with classic GCA.

Giant calcinosis revealing systemic sclerosis.

Calcinosis is a complication of systemic sclerosis, most often occurring more than several years after diagnosis. We report the case of a man who developed severe calcinosis in shoulders and hips occurring before other systemic sclerosis' symptoms.

Efficacy of tocilizumab in Takayasu arteritis: Multicenter retrospective study of 46 patients.

Objectives: To assess the efficacy of tocilizumab in patients with Takayasu arteritis (TA).

Methods: We conducted a retrospective multicenter study in 46 TA patients treated with tocilizumab. We analyzed factors associated with response to tocilizumab (assessed using NIH score).

Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review.

Background: Cogan syndrome is mainly treated with steroids. We aimed to determine the place of DMARDs and biologic-targeted treatments.

Patients And Methods: We conducted a French nationwide retrospective study of patients with Cogan syndrome (n=40) and a literature review of cases (n=22) and analyzed the efficacy of disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor α (TNF-α) antagonists.

Kawasaki disease in adults: Observations in France and literature review.

Objective: Kawasaki disease (KD) is a vasculitis that mostly occurs in young children and rarely in adults. We analyzed the characteristics of adult-onset KD (AKD) in France.

Methods: We collected retrospective and prospective data for patients with a diagnosis of KD occurring after the age of 18 years.

Global positioning system use in the community to evaluate improvements in walking after revascularization: a prospective multicenter study with 6-month follow-up in patients with peripheral arterial disease.

Unlabelled: Revascularization aims at improving walking ability in patients with arterial claudication. The highest measured distance between 2 stops (highest-MDCW), the average walking speed (average-WSCW), and the average stop duration (average-DSCW) can be measured by global positioning system, but their evolution after revascularization is unknown.We included 251 peripheral artery diseased patients with self-reported limiting claudication.

Outcome of anti-PL12 positive patients with antisynthetase syndrome.

Objectives: The aim of the present study was to assess the outcome in anti-PL12 patients with antisynthetase syndrome (ASS).

Methods: The medical records of anti-PL12 (n=5) patients with ASS were retrospectively analyzed without prior selection. To exclude false-positive patients, we included patients who were successively tested positive for anti-PL12 antibody at least twice by immunodot and/or Western blot.

IgG4-related systemic disease: features and treatment response in a French cohort: results of a multicenter registry.

IgG4-related systemic disease is now recognized as a systemic disease that may affect various organs. The diagnosis is usually made in patients who present with elevated IgG4 in serum and tissue infiltration of diseased organs by numerous IgG4+ plasma cells, in the absence of validated diagnosis criteria. We report the clinical, laboratory, and histologic characteristics of 25 patients from a French nationwide cohort.

Kawasaki disease in adults: report of 10 cases.

Kawasaki disease (KD) is an acute multisystemic vasculitis occurring predominantly in children and rarely in adults. Diagnosis is made clinically using diagnostic guidelines; no specific test is available. "Incomplete" KD is a more recent concept, which refers to patients with fever lasting > or =5 days and 2 or 3 clinical criteria (rash, conjunctivitis, oral mucosal changes, changes of extremities, adenopathy), without reasonable explanation for the illness.

African trypanosomiasis acquired in an urban area.

A 28-year-old Zairian woman was presented with a diurnal somnolence, cervical polyadenopathy, splenomegaly, eosinophilia, and elevated IgM. A diagnosis of West African trypanosomiasis was confirmed and the patient improved after treatment with eflornithine.

Characteristics of brain abscess with isolation of anaerobic bacteria.

In view of its localization, brain abscess (BA) usually requires medical and surgical care. A broad spectrum of bacteria is involved. Recent reports stress the increasing frequency of anaerobes, but their impact has not been well evaluated.

[Arizonae subspecies Salmonella enterica urinary infection with confusional syndrome].

Introduction: Infections due to subspecies arizonae Salmonella enterica are rare. These infections are transmitted by reptiles. We report the case of S.

Meningitis due to Capnocytophaga canimorsus after receipt of a dog bite: case report and review of the literature.

We describe a case of meningitis due to Capnocytophaga canimorsus and review 18 cases with attention to risk factors, clinical features, diagnosis, treatment, and outcome. In most of the reported cases, contact with dogs and predisposing factors were found. Clinical manifestations and the findings of examinations of cerebrospinal fluid specimens were similar to those of classic bacterial meningitis; however, the mortality rate for C.

Central venous catheter-related infection due to Agrobacterium radiobacter: a report of 2 cases.

We report 2 cases of Agrobacterium radiobacter bacteremia in immunocompromised patients. Removal of the central venous catheter and administration of antimicrobial therapy led to favorable outcomes in both patients. Infections due to A.