The chemical investigation of the total alkaloid extract (TAE) of the stem bark of (Rutaceae) afforded an unreported indolopyridoquinazoline (compound ) along with nine previously known alkaloids -. In addition, six semi-synthetic derivatives -, , and were prepared by allylation and acetonidation of soyauxinium nitrate (), edulinine (), ribalinine () and arborinine (). The structures and spectroscopic data of five of them are reported herein for the first time.
View Article and Find Full Text PDFThe cytotoxic potential of a naturally occurring indoloquinazoline alkaloid, soyauxinium chloride (SCHL), was determined on a broad panel of animal and human cancer cell lines, including various sensitive and drug-resistant phenotypes. The cytotoxicity, SCHL-induced autophagic, ferroptotic, and necroptotic cell death were evaluated by the resazurin reduction assay (RRA). Caspase-Glo assay was used to detect the activity of caspases using spectrophotometric analysis.
View Article and Find Full Text PDFEthnopharmacological Relevance: Araliopsis soyauxii Engl. (Rutaceae) is a Cameroonian medicinal plant traditionally used to treat lung diseases, malaria, and gonorrhea. It has been demonstrated that infectious disease contribute to about 20% of all human tumours.
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