Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits.

The lateral hypothalamus (LH) is a key regulator of multiple vital behaviors. The firing of brain-wide-projecting LH neurons releases neuropeptides promoting wakefulness (orexin/hypocretin; OH), or sleep (melanin-concentrating hormone; MCH). OH neurons, which coexpress glutamate and dynorphin, have been proposed to excite their neighbors, including MCH neurons, suggesting that LH may sometimes coengage its antagonistic outputs.

Three-dimensional parabolic equation model for low frequency sound propagation in irregular urban canyons.

A three-dimensional wide-angle parabolic equation (3DPE) is used to model low frequency sound propagation in irregular urban canyons at low computational cost. This one-way wave equation is solved using the Alternating Direction Implicit method. A finite difference scheme adapted to the geometry of the urban environment is then developed.