Publications by authors named "Cedric Duron"
Background: Patients with cirrhosis are at high risk of thrombotic events, including portal vein thrombosis and venous thromboembolism. In such patients, hypercoagulability is not detected by conventional coagulation tests, but only by the thrombin generation assay (TGA) that integrates the role of pro- and anticoagulant factors. However, TGA use to predict clinical events depends on thrombin generation variability over time.
View Article and Find Full Text PDFExtrahepatic portal vein obstruction (EHPVO) in cirrhosis.
Clin Res Hepatol Gastroenterol
September 2020
Background And Aims: Cirrhosis significantly changes all hemostasis steps. Recent studies suggest that cirrhosis is associated with a coagulopathy leading to a hypercoagulable state. The underlying mechanisms are not fully understood, but protein C deficiency is probably a major determinant of this phenotype.
View Article and Find Full Text PDFArticle Synopsis
- Cirrhosis alters hemostatic balance, reducing both procoagulant and anticoagulant factors, making traditional tests ineffective for assessing thrombotic risk.
- This study analyzed coagulation in 30 cirrhotic patients using thrombinography, revealing significantly higher thrombin potential ratios compared to healthy controls, indicating a resistance to activated protein C pathways.
- Findings suggest that rather than being anticoagulated, cirrhotic patients may experience increased hypercoagulability, especially with advanced disease severity, challenging existing beliefs about their coagulation status.*
Background: An acute infusion reaction during infliximab infusions could lead to drug withdrawal and limit the therapeutic armamentarium in inflammatory bowel diseases.
Aim: To determine the risk and protective factors of an acute infusion reaction.
Materials And Methods: Data were retrieved retrospectively from electronic charts of patients from the 'Clermont-Ferrand IBD cohort'.