Polio survivors perceptions of a multi-disciplinary rehabilitation programme.

Purpose: Post-polio syndrome refers to a late complication of the poliovirus infection. Management of post-polio syndrome is complex due to the extensive symptomology. European and United Kingdom guidelines have advised the use of rehabilitation programmes to manage post-polio syndrome.

A research-based mantra for compassionate caring.

Background: The United Kingdom introduced the Six C's strategy to help address deficits in approaching nursing care in a compassionate and caring manner.

Objective: To identify the book, article, poem, film or play that most influenced nurse educators' understanding of care and compassion and to articulate a clearer understanding of compassionate caring.

Design: A qualitative study applying discourse analysis to respondents' questionnaires and their nominated narrative.

A moral profession: Nurse educators' selected narratives of care and compassion.

Background:: Lack of compassion is claimed to result in poor and sometimes harmful nursing care. Developing strategies to encourage compassionate caring behaviours are important because there is evidence to suggest a connection between having a moral orientation such as compassion and resulting caring behaviour in practice.

Objective:: This study aimed to articulate a clearer understanding of compassionate caring via nurse educators' selection and use of published texts and film.

Human embryonic stem cells: a model for human ageing in vitro.

Stem cells have been used to investigate developmental processes and may be used as a therapeutic source of material for regenerative medicine and cancer. Here we propose the use of human embryonic stem cells, which represent a youthful phenotype, as models for experimentally investigating human ageing.

The therapeutic potential of human embryonic stem cells.

Due to lack of suitable organ donors, future degenerative diseases and traumas could be treated with stem cell engraftment. To do this, large numbers of cells must be grown and maintained in culture. These cells must also be capable to differentiate into all the cells of the body.

From embryos to embryonic stem cells: biopolitics and therapeutic potential.

The inner cell mass of the preimplantation blastocyst, from which all the cells of the body develop, is a source of embryonic stem cells. These cells can be maintained in their undifferentiated state over long periods in culture and yet retain their pluripotency. The generation of human stem cells capable of differentiating into all the cell types of the human body opens the way for the use of these cells in therapeutic transplantation for a myriad of diseases.

From embryos to embryonic stem cells: biopolitics and therapeutic potential.

The inner cell mass of the preimplantation blastocyst, from which all the cells of the body develop, is a source of embryonic stem cells. These cells can be maintained in their undifferentiated state over long periods in culture and yet retain their pluripotency. The generation of human stem cells capable of differentiating into all the cell types of the human body opens the way for the use of these cells in therapeutic transplantation for a myriad of diseases.

Stem cell and related therapies: nurses and midwives representing all parties.

Nurses and midwives are part of health care in all the stages of our lives from preconception to death. Recent scientific advances have introduced new techniques of screening and diagnosis linked to stem cell isolation and therapies. These could affect us at any age and therefore nurses will be involved as carers and patients advocates for these techniques.

The function of stem cells and their future roles in healthcare.

Adult stem cells from bone marrow have been used in the treatment of cancer for many years. Recently, however, interest has developed in the isolation and growth of adult, cord and embryonic stem cells for use in regenerative medicine. Their therapeutic use will undoubtedly be implemented in nursing practice in a variety of clinical areas.

An overview of education and 'new genetics'.

Research and development in the field of genetics and the Human Genome Project will have a major impact on the future of health care and the services on offer for users. The authors discuss the importance of educating nurses about genetic developments so that they can apply this knowledge to practice.

Multiple differentiation programs in K562 erythroleukemia cells and their regulation.

The chronic myeloid leukemia-derived cell line K562 expresses, in its uninduced state, notable erythroid features. However, in addition to the presence of well-characterized "erythroid-specific" molecules, such as hemoglobin and glycophorin A, there is increasing evidence of both granulopoietic and megakaryocytic differentiation in this cell line. In this chapter we have further characterized erythroid and nonerythroid features in order to investigate the range of differentiation programs expressed by uninduced K562 cells.

Expression of red cell specific determinants during differentiation in the K562 erythroleukaemia cell line.

A human haemopoietic cell line (K562) which exhibits various erythroid characteristics, has been utilised as a model system for studying erythropoietic differentiation. We have analysed the alterations in expression of cell membrane determinants which accompany the induction of Hb synthesis. We confirm that the K562 cell line exhibits a number of erythroid features: it expresses immunologically detectable membrane proteins, glycophorin A and spectrin and can ber induced, by addition of haemin or n-butyrate, to synthesise Hb.