Synchronous and metachronous liver metastases in patients with colorectal cancer.

Introduction: Liver metastases are the most common complication to colorectal cancer, and the presence of metastatic disease severely impacts the overall prognosis of the disease. Since the diagnostic work-up of metastasised colorectal cancer has undergone tremendous changes in past decades, an impact on the incidence of metastatic disease is anticipated. The aim of this study was to evaluate the incidence and prognosis of liver metastasis in patients with colorectal cancer.

The optimal lymph node dissection in patients with adenocarcinoma of the esophagogastric junction.

Objective: The aim of this study was to refine the optimal lymph node dissection in Western patients with adenocarcinoma of the esophagogastric junction (AEG).

Background: Lymphadenectomy is essential in addition to surgery for AEG. Asian studies continually present superior survival rates using a more extended lymphadenectomy compared with results reproduced in the West.

Cheek Numbness Caused by Perineural Tumor Invasion of the Infraorbital Nerve: A Review of 3 Diagnostically Challenging Cases.

BACKGROUND Facial pain and numbness are common symptoms with a variety of causes; rarely, it is an initial sign of perineural infiltration of malignant tumors. CASE REPORT Here, we report 3 challenging cases, all presenting with pain and numbness of the cheek as the primary symptoms. Upon referral, there were neither signs of severe illness nor information about previous malignant diseases, while the diagnostic work-ups revealed additional involvement of the facial nerve in 2 of the cases.

Ketorolac and Other NSAIDs Increase the Risk of Anastomotic Leakage After Surgery for GEJ Cancers: a Cohort Study of 557 Patients.

Objective: The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer. Within the last two decades, the incidence of gastro-esophageal-junction cancer has increased in the western world and surgery is the curative treatment modality of choice. Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality.

Preoperative CT versus diffusion weighted magnetic resonance imaging of the liver in patients with rectal cancer; a prospective randomized trial.

Introduction. Colorectal cancer is one of the most frequent cancers in the world and liver metastases are seen in up to 19% of patients with colorectal cancers. Detection of liver metastases is not only vital for sufficient treatment and survival, but also for a better estimation of prognosis.

Perioperative Colonic Evaluation in Patients with Rectal Cancer; MR Colonography Versus Standard Care.

Rationale And Objectives: Preoperative colonic evaluation is often inadequate because of cancer stenosis making a full conventional colonoscopy (CC) impossible. In several studies, cancer stenosis has been shown in up to 16%-34% of patients with colorectal cancer. The purpose of this study was to prospectively evaluate the completion rate of preoperative colonic evaluation and the quality of perioperative colonic evaluation using magnetic resonance colonography (MRC) in patients with rectal cancer.

[Circulating tumour cells is a promising prognostic and predictive marker of gastric cancer].

Despite chemotherapy and intended curative surgery, approximately 50% of patients with gastric cancer develop recurrence and eventually die of metastatic disease. The detection of circulating tumour cells (CTC) in peripheral blood is a promising prognostic and predictive marker. The most typically applied approaches to the detection of CTC are RT-PCR and immunological assays.

Number of published randomized controlled multi center trials testing pharmacological interventions or devices is increasing in both medical and surgical specialties.

Background: In general, there is a need for testing new interventions in large randomized controlled trials. Depending on the research question it may be advantageous to establish multicenter studies as a way of organizing clinical trials in order to increase study power.

Main Objectives: The object of this study was to investigate the development in the organization of multicenter studies, the distribution of studies within different clinical specialties, across continents, and investigate the differences related to testing various interventions.

Status and prognosis of lymph node metastasis in patients with cardia cancer - a systematic review.

Background: Adenocarcinoma of the gastroesophageal junction (GEJ) has a poor prognosis and survival rates significantly decreases if lymph node metastasis is present. An extensive lymphadenectomy may increase chances of cure, but may also lead to further postoperative morbidity and mortality. Therefore, the optimal treatment of cardia cancer remains controversial.

Inflammatory response in laparoscopic vs. open surgery for gastric cancer.

Objective: Laparoscopic surgery may offer advantages compared to open surgery, such as earlier mobilization, less pain and lower post-surgical morbidity. Surgical stress is thought to be associated with the postoperative immunological changes in the body as an impaired immune function, which may lead to an increased susceptibility to complications and morbidity. The aim of this review was to investigate if laparoscopic surgery reduces the immunological response compared to open surgery in gastric cancer.

No increased risk of perforation during colonoscopy in patients undergoing Nurse Administered Propofol Sedation.

Objective: Nurse Administered Propofol Sedation (NAPS) contributes to a deeper sedation of the patients, making them unable to respond to pain and an increased incidence of perforations has been speculated. The objective of this study was to evaluate the risk of perforations during colonoscopies performed with either NAPS or conventional sedation regimes.

Material And Methods: Data were retrospectively retracted from medical journals from 1 January 2007 to 31 December 2011.