Publications by authors named "Cecilie F Torkildsen"
Article Synopsis
- Secondary cytoreductive surgery may be beneficial for patients with relapsed platinum-sensitive epithelial ovarian cancer, but guidelines for its use are lacking.
- A systematic review of published studies found that combining surgery with chemotherapy improved progression-free survival, but the effects on overall survival varied across different studies.
- Well-defined patient selection criteria are essential to enhance overall survival rates when considering cytoreductive surgery alongside standard chemotherapy for recurrent cases.
Despite advances in surgical and therapeutic approaches, high-grade serous ovarian carcinoma (HGSOC) prognosis remains poor. Surgery is an indispensable component of therapeutic protocols, as removal of all visible tumor lesions (cytoreduction) profoundly improves the overall survival. Enhanced predictive tools for assessing cytoreduction are essential to optimize therapeutic precision.
View Article and Find Full Text PDFBackground: High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain inadequate for anticipating the outcomes of the complex relationship between tumour biology, clinical phenotypes, co-morbidity and surgical skills. In this genotype-phenotype association study, we combine phenotypic markers with targeted DNA sequencing to discover novel biomarkers to guide the surgical management of primary HGSOC.
View Article and Find Full Text PDFHigh-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict surgical outcome and recurrence risk and resistance, reproducible indicators are scarce.
View Article and Find Full Text PDFHigh-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, contextualized preclinical models are required to secure meaningful clinical translation.
View Article and Find Full Text PDFBackground: Knowledge concerning exposure to abuse in adulthood and in pregnancy in people with multiple sclerosis (MS) is sparse.
Objective: To determine the occurrence of adult abuse and abuse in relation to pregnancy in women with MS and their risk of revictimization (repeated abuse as adults after childhood abuse).
Methods: This cross-sectional study comprised pregnant women from the Norwegian Mother, Father and Child Cohort study.
Association of adverse childhood experiences with the development of multiple sclerosis.
J Neurol Neurosurg Psychiatry
June 2022
Objective: To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development.
Methods: A nationwide, prospective cohort study based on participants in the Norwegian Mother, Father and Child cohort study. Enrolment took place 1999-2008, with follow-up until 31 December 2018.
Article Synopsis
- The study aimed to evaluate the rates of perinatal depression and anxiety in women diagnosed with multiple sclerosis (MS) before and after pregnancy.
- A large cohort of 114,629 pregnant women was analyzed, and findings indicated that those with MS diagnosed before pregnancy had a higher likelihood of experiencing depression in the third trimester, while postpartum diagnoses led to an increased risk of postpartum depression.
- The results highlight that women who developed MS symptoms within 5 years post-pregnancy faced a greater risk for both depression and anxiety during pregnancy, unlike those with later symptom onset.
A pregnant woman with acute abdomen.
Tidsskr Nor Laegeforen
April 2021
Background: Acute abdomen in pregnancy is challenging. The presentation of symptoms and available diagnostic tools are directed and complicated by the pregnancy. A rare cause of acute abdomen in pregnancy requiring immediate intervention is presented.
View Article and Find Full Text PDFThe aim of the present study was to assess indications for induction and describe the characteristics and delivery outcome in medical compared to non-medical/elective inductions. During a three-month period, 1663 term inductions were registered in 24 delivery units in Norway. Inclusion criteria were singleton pregnancies with cephalic presentation at gestational age 37+0 and beyond.
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