Publications by authors named "Cecilia T Morales-De-la-Pena"

We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates of ( = 3985), ( = 775), ( = 163), ( = 781), ( = 124), and ( = 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) and the disk diffusion susceptibility method (6/43). The presence of carbapenemase-encoding genes was assessed using PCR.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to analyze the genomic features and molecular epidemiology of carbapenem-resistant bacteria like Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in Mexico using whole genome sequencing and bioinformatics tools.
  • Clinical isolates were collected from 28 medical centers, and various genetic resistance and virulence factors were identified in these bacteria, indicating a significant presence of resistance genes across the studied strains.
  • The findings highlight the prevalence of multiple resistance genes in the tested bacteria, suggesting urgent attention is needed for managing antibiotic resistance in clinical settings in Mexico.
View Article and Find Full Text PDF

Background: Antimicrobial resistance is a global concern. Analysis of sterile fluids is essential because microorganisms are defined as significant in most cases. Blood, cerebrospinal, and pleural fluids are frequently received in the microbiology lab because they are associated with considerable rates of morbi-mortality.

View Article and Find Full Text PDF

Fosfomycin is currently a viable option against urinary tract infections, particularly against extended-spectrum β-lactamases (ESBL)-producing , due to its unique mechanism of action and its low resistance among bacteria. The objective of this study was to investigate two of the three most common mechanisms of resistance against this antibiotic among 350 ESBL-producing strains isolated from the urine of Mexican patients. The prevalence of fosfomycin resistance in our study was 10.

View Article and Find Full Text PDF

This study aims to assess the changes in antimicrobial resistance among some critical and high-priority microorganisms collected previously and during the coronavirus disease 2019 (COVID-19) pandemic in Mexico. We collected antimicrobial susceptibility data for critical and high-priority microorganisms from blood, urine, respiratory samples, and from all specimens, in which the pathogen may be considered a causative agent. Data were stratified and compared for two periods: 2019 versus 2020 and second semester 2019 (prepandemic) versus the second semester 2020 (pandemic).

View Article and Find Full Text PDF

Aim: This report presents phenotypic and genetic data on the prevalence and characteristics of extended-spectrum β-lactamases (ESBLs) and representative carbapenemases-producing Gram-negative species in Mexico.

Material And Methods: A total of 52 centers participated, 43 hospital-based laboratories and 9 external laboratories. The distribution of antimicrobial resistance data for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, Acinetobacter baumannii complex, and Pseudomonas aeruginosa in selected clinical specimens from January 1 to March 31, 2020 was analyzed using the WHONET 5.

View Article and Find Full Text PDF

Surveillance of antimicrobial resistance (AMR) requires an international approach with national and local strategies. Our aim was to summarize a retrospective 10-year report of antibiotic resistance of gram-positive and gram-negative bacteria in Mexico. A total of 46 centers from 22 states of Mexico participated.

View Article and Find Full Text PDF

Aim: We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens of epidemiological importance in 47 Mexican centers.

Material And Methods: In this retrospective study, we included a stratified sample of 47 centers, covering 20 Mexican states. Selected isolates considered as potential causatives of disease collected over a 6-month period were included.

View Article and Find Full Text PDF