Publications by authors named "Cecilia Renee Schaaf"
HOPX injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia.
Am J Physiol Gastrointest Liver Physiol
November 2021
Article Synopsis
- - Intestinal ischemia is a serious condition with high mortality rates (50%-80%) due to the death of epithelial cells and loss of the gut's protective barrier, impacted by conditions like intestinal volvulus and neonatal necrotizing enterocolitis.
- - Intestinal epithelial stem cells (ISCs) play a key role in repairing the epithelial barrier post-injury, with two main types identified: active ISCs (highly proliferative) and reserve ISCs (less proliferative). Both have been studied through a porcine model to understand their recovery roles after ischemic injury.
- - Findings indicate that reserve ISCs (rISCs), particularly those marked by HOPX, remain inactive during early recovery but show a decrease in