Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of (Schum. and Thonn) in -infected mice.

Objectives: Broad spectrum antimalarial drugs without deleterious effects on mitochondria are scarce. It is in this regard that we investigated the potency of methanol extract and solvent fractions of on chloroquine-susceptible and resistant strains of , toxicity and its consequential effects on mitochondrial permeability transition (mPT) pore opening.

Methods: Malaria was induced in male Swiss mice with susceptible (NK 65) strain, divided into groups (n=5) and treated with 100, 200 and 400 mg/kg of methanol extract, -hexane, dichloromethane, ethylacetate and methanol fractions daily for seven days.