Increased Expression of Autophagy Protein LC3 in Two Patients With Progressing Chronic Lymphocytic Leukemia.

Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in the western hemisphere. It is characterized by a clonal proliferation of a population of CD5+ B lymphocytes that accumulate in the secondary lymphoid tissues, bone marrow, and blood. Some CLL patients remain free of symptoms for decades, whereas others rapidly become symptomatic or develop high-risk disease.

Tumor-stroma interaction increases CD147 expression in neoplastic B lymphocytes in chronic lymphocytic leukemia.

Background: Chronic lymphocytic leukemia (CLL) microenvironment plays a critical role in disease pathogenesis. Matrix metalloproteinases (MMPs) are involved in CLL-B cell migration and survival. CD147 is associated with MMPs production by tumor and stromal cells.

[CD4+CD25+CD127low (Treg) cell numbers in patients with allergic rhinitis with and without immunotherapy].

Background: Allergic rhinitis and asthma are the most common chronic inflammatory diseases affecting the respiratory tract. A subgroup of regulatory T cells, CD4+CD25+, participates in the control of allergic diseases.

Objetive: To determine if there is a difference in the number of peripheral blood regulatory T cells, identified as CD4+CD25+CD127low, of patients with rhinitis compared to healthy controls; if there is correlation of the number of these cells with other manifestations of the disease and if that number changes in the same individual after immunotherapy.