Publications by authors named "Cecilia Horta Ramalho Pinto"
Article Synopsis
- Identifying biomarkers for COVID-19 outcomes is essential for better managing high-risk patients and improving survival chances, particularly through early antiviral medication administration.
- A study involving 297 COVID-19 patients in Belo Horizonte, Brazil, explored the relationship between hematological parameters and disease severity using statistical analysis and machine learning.
- Findings indicate that monocyte percentage and granulocyte-to-lymphocyte ratio can effectively predict hospitalization risk, making these simple blood test parameters valuable tools for managing treatment in various healthcare settings.
Chagas disease, a neglected disease caused by the protozoan , is endemic in 21 Latin American countries, affecting 6-8 million people. Increasing numbers of Chagas disease cases have also been reported in non-endemic countries due to migration, contamination via blood transfusions or organ transplantation, characterizing Chagas as an emerging disease in such regions. While most individuals in the chronic phase of Chagas disease remain in an asymptomatic clinical form named indeterminate, approximately 30% of the patients develop a cardiomyopathy that is amongst the deadliest cardiopathies known.
View Article and Find Full Text PDFSARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach.
Inflammation
February 2023
Hyper-transmissibility with decreased disease severity is a typical characteristic of the SARS-CoV-2 Omicron variant. To understand this phenomenon, we used various bioinformatics approaches to analyze randomly selected genome sequences (one each) of the Gamma, Delta, and Omicron variants submitted to NCBI from December 15 to 31, 2021. We report that the pathogenicity of SARS-CoV-2 variants decreases in the order of Wuhan > Gamma > Delta > Omicron; however, the antigenic property follows the order of Omicron > Gamma > Wuhan > Delta.
View Article and Find Full Text PDFSince December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far.
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