Surface topography modulates initial platelet adhesion to titanium substrata.

The clinical success of implanted biomaterials such as dental implants is largely determined by the molecular signaling that occurs at the tissue-implant interface. The modification of surface topography is a widely-employed strategy for optimizing tissue integration with dental implants. However, little is known regarding the direct, cellular-level effects of substratum topography on platelet signaling and adhesion, despite these cells being the first to encounter the implant surface during surgical placement.

The effects of surface treatments on tensile bond strength of polyether-ketone-ketone (PEKK) to veneering resin.

Objectives: To test the different PEKK surface treatment methods on the tensile bond strength (TBS) of a resin composite to PEKK.

Methods: Two hundred and fifty polished PEKK specimens were fabricated, divided into 5 groups (n = 50) and underwent the following treatments: no pre-treatment (control group C), 110 µm AlO gritblasting at 2 bar for 10 s (Group Al), 98 wt% sulfuric acid etching for 60 s (Group SA), tribochemical silica-coating through air-abrasion with Rocatec Plus 110 µm at 2 bar for 10 s (Group Trib), and sulfuric acid etching and subsequent tribochemical silica-coating (Group SATrib). Ten specimens in each group were taken out for surface characterization.

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to release of PF4 has dissipated. We asked whether antigenic complexes between polyphosphates and PF4 released from activated platelets might intensify or sustain the prothrombotic phenotype of HIT.

Effects of different blasting materials on charge generation and decay on titanium surface after sandblasting.

It has been reported that sandblasting titanium with alumina (Al2O3) powder could generate a negative electric charge on titanium surface. This has been proven to promote osteoblast activities and possibly osseointegration. The purpose of this pilot study was to investigate the effects of different blasting materials, in terms of the grit sizes and electro-negativity, on the generation of a negative charge on the titanium surface.

Effects of surface charges on dental implants: past, present, and future.

Osseointegration is a major factor influencing the success of dental implantation. To achieve rapid and strong, durable osseointegration, biomaterial researchers have investigated various surface treatment methods for dental subgingival titanium (Ti) implants. This paper focuses on surface-charge modification on the surface of titanium dental implants, which is a relatively new and very promising methodology for improving the implants' osseointegration properties.