Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections.

Retrospective studies have documented a significant association between linezolid (LNZ) plasma concentrations and drug-related haematological toxicity. However, the safe upper threshold level for LNZ plasma trough concentrations (Cmin values) has not been defined with certainty. A prospective observational study was performed aimed at comparing LNZ Cmin values in patients developing drug-related side effects with those measured in patients not experiencing LNZ toxicity.

Risk factors for lipodystrophy in the CISAI cohort.

Purpose: This study set out to describe the frequency of lipodystrophy, and identify its risk factors, in HIV-positive patients treated with HAART containing at least one protease inhibitor (PI). We analyzed the data collected in the CISAI study.

Methods: The CISAI is a multicenter cohort study that has enrolled 1480 patients.