Publications by authors named "Cecilia Delprete"

The gustatory system is responsible for detecting and evaluating the palatability of the various chemicals present in food and beverages. Taste bud cells, located primarily on the tongue, communicate with the gustatory sensory neurons by means of neurochemical signals, transmitting taste information to the brain. It has also been found that the endocannabinoid system (ECS) may modulate food intake and palatability, and that taste bud cells express cannabinoid receptors.

View Article and Find Full Text PDF
Article Synopsis
  • Fabry disease is a rare genetic disorder caused by a deficiency in an enzyme, leading to accumulation of certain lipids in body cells and impacting the gastrointestinal (GI) system, often manifesting early in the disease.
  • The study aimed to explore how the lipid lyso-Gb affects ion transport and motility in mouse colons, finding that it increases colonic ion transport without relying on chloride ions or involving the enteric nervous system.
  • Results suggest that while lyso-Gb affects ion transport in the colon, other factors may be needed to cause the severe GI issues seen in Fabry disease patients.
View Article and Find Full Text PDF

The endocannabinoid system (ECS) has emerged as a potential therapeutic target in veterinary medicine due to its involvement in a wide range of physiological processes including pain, inflammation, immune function, and neurological function. Modulation of the ECS receptors has been shown to have anti-inflammatory, analgesic, and immunomodulatory effects in various animal models of disease, including dogs with osteoarthritis. The goal of this study was to identify and compare the cellular expression and distribution of cannabinoid receptor type 1 (CB1R) and type 2 (CB2R) and the cannabinoid-related G protein-coupled receptor 55 (GPR55) on the synovial cells of hip and stifle joints of seven dogs of different breeds without overt signs of osteoarthritis (OA).

View Article and Find Full Text PDF

Fabry disease (FD) is a X-linked lysosomal storage disorder caused by deficient function of the alpha-galactosidase A (α-GalA) enzyme. α-GalA deficiency leads to multisystemic clinical manifestations caused by the preferential accumulation of globotriaosylceramide (Gb3). A hallmark symptom of FD patients is neuropathic pain that appears in the early stage of the disease as a result of peripheral small fiber damage.

View Article and Find Full Text PDF

To improve pathogenetic studies in cancer development and reliable preclinical testing of anti-cancer treatments, three-dimensional (3D) cultures, including spheroids, have been widely recognized as more physiologically relevant models of in tumor behavior. Currently, the generation of uniformly sized spheroids is still challenging: different 3D cell culture methods produce heterogeneous populations in dimensions and morphology, that may strongly influence readouts reliability correlated to tumor growth rate or antitumor natural killer (NK) cell-mediated cytotoxicity. In this context, an increasing consensus claims the integration of microfluidic technologies within 3D cell culture, as the physical characterization of tumor spheroids is unavoidably demanded to standardize protocols and assays for testing.

View Article and Find Full Text PDF
Article Synopsis
  • Accurate measurement of mass density, size, and weight of cells, especially in cancer research, is crucial but often lacking for 3D models like spheroids.
  • The text introduces a flow-apparatus and method for measuring these parameters by detecting the terminal velocity of free-falling samples.
  • Initial experiments using standardized polystyrene beads demonstrate the device's precision, and the system was successfully applied to analyze live SW620 tumor spheroids, enhancing understanding of 3D culture models.
View Article and Find Full Text PDF

Background: Fabry disease (FD) is a hereditary X-linked metabolic storage disorder characterized by deficient or absent lysosomal α-galactosidase A (α-Gal A) activity. This deficiency causes progressive accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), in nearly all organ systems. Gastrointestinal (GI) symptoms can be very debilitating and are among the most frequent and earliest of the disease.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionqb2m2gsbn0l5kqd4iivo7u9tf1lsaeg4): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once