Publications by authors named "Cecilia Beatriz Di Capua"
Article Synopsis
- Trypanosoma cruzi, a parasite reliant on heme, regulates its heme levels by adjusting the expression of a specific protein called TcHRG when exposed to free heme in culture.
- The study found that TcHRG responds similarly to both bound (hemoglobin) and free heme, located near the flagellar pocket and mitochondria.
- Interestingly, despite the absence of endocytosis, parasites can still acquire heme from hemoglobin, suggesting that TcHRG plays a key role in breaking down hemoglobin to extract heme from outside the cell through the flagellar pocket.
, a heme auxotrophic parasite, can control intracellular heme content by modulating HRG expression when a free heme source is added to axenic culture. Herein, we explore the role of HRG protein in regulating the uptake of heme derived from hemoglobin in epimastigotes. It was found that the parasités endogenous HRG (protein and mRNA) responds similarly to bound (hemoglobin) and free (hemin) heme.
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