Publications by authors named "Cecilia Araujo Carneiro Lima"
Article Synopsis
- The study investigates the levels of various soluble immune mediators in gastric cancer (GC) patients compared to healthy controls, focusing on potential therapeutic targets for treatment.
- Results indicate low levels of sPD-1, sPD-L2, and sGal9, while levels of sPD-L1, sTIM-3, sGITR, and sGITRL were higher in GC patients, with variations based on cancer stages and specific tumor locations.
- Findings suggest a potential link between certain soluble mediators (sPD-1, sTIM-3, sGal9) and disease progression, as well as the association of low sGITR with increased mortality within the first
Background And Objectives: Previous studies have demonstrated that soluble forms of T-cell costimulatory molecules 4-1BB (s4-1BB) and OX40 (sOX40) interact with immune cells and may constitute a mechanism of immune evasion by tumors in various cancers. The role of the soluble forms of 4-1BB and OX40 in GC remains unclear. We aimed to examine the association between serum levels of s4-1BB and sOX40 and tumor progression in patients with GC.
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