Prevalence of metabolic syndrome in children aged 5-9 years from southwest colombia: a cross-sectional study.

Background: Exploration of cardiometabolic alterations in the pre-adolescent stage is necessary to characterize possible patterns for matabolic syndrome (MetS) in the earliest stages of the life. However, defining specific cutoff points for metabolic and vascular markers represents a complex task in pre-adolescent populations. This study aimed to estimate the prevalence of MetS and its components in children aged 5-9 years old by using the MetS definition for adolescents with the lowest cut-off points, and evaluate its relationship with overweight and socio-demographic determinants.

Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects.

Scope: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non-diabetic controls and to evaluate the effect of metformin on hepcidin concentrations.

Waist:height ratio, waist circumference and metabolic syndrome abnormalities in Colombian schooled adolescents: a multivariate analysis considering located adiposity.

Very few large studies in Latin America have evaluated the association between waist:height ratio (W-HtR) and cardiometabolic risk in children and adolescents. Further, multivariable analyses verifying the independence of located subcutaneous fat have not been conducted so far. The aim of this study was to evaluate the associations of W-HtR and waist circumference (WC) with metabolic syndrome abnormalities and high LDL-cholesterol levels in schooled adolescents before and after adjusting for trunk skinfolds and BMI.

Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases.

Epidemiological studies have led scientists to postulate the developmental origins of health and disease hypothesis for noncommunicable diseases such as diabetes, cardiovascular diseases, hypertension, and obesity. However, the cellular and molecular mechanisms involved in the development of these diseases are not well understood. In various animal models, it has been observed that oxidative stress during pregnancy is associated with the early development of endothelial dysfunction in offspring.

Relationship between maternal and newborn endothelial function and oxidative stress.

Objective: To evaluate the Relationship between maternal and newborn endothelial function and oxidative stress.

Methods: Forty-three pregnant women and their offspring were evaluated. As markers of endothelial function, the flow-mediated dilation (FMD) was measured in pregnant women in the second and third trimesters, and nitric oxide (NO) was quantified in the endothelial cells of the umbilical cord vein.

Evaluation of the relationship between self-reported physical activity and metabolic syndrome and its components in apparently healthy women.

Introduction: The metabolic syndrome, a set of metabolic anomalies that include insulin resistance, central obesity, dyslipidemia, hypertension and inflammation, is an important tool to explore factors associated to cardiometabolic disease.

Objective: The aim of this study was to evaluate the relationship of the levels of self-reported physical activity and the International Physical Activity Questionnaire items and the metabolic syndrome and the variables related to cardiovascular risk in 89 women.

Materials And Methods: The short version of International Physical Activity Questionnaire was applied to classify participating subjects into three categories: insufficient, sufficient and very active physical activity.

Early atherosclerotic lesions and post-mortem serum cholesterol level in a group of Colombian children.

Introduction: Atherosclerosis is an asymptomatic chronic disease, which begins at early age and is difficult to detect during this stage. Prospective studies suggest a causal relationship between total serum cholesterol levels during childhood and early adolescence and the development of cardiovascular diseases in adulthood.

Objective: The aim of this study was to evaluate the prevalence of early atherosclerotic lesions in the aorta artery of children and its relationship with post-mortem serum cholesterol levels.

Association of self-reported familial history of cardiometabolic disease with metabolic syndrome in apparently healthy urban Colombian men.

Objectives: Evidence about the relationship between familial history (FH) of cardiometabolic disease (CMD) and metabolic syndrome (MetS) in Latin American populations is scarce. The aim of this study was to evaluate the relationship of FH of CMD and of dyslipidemia and obesity with MetS in healthy men.

Methods: One-hundred-twenty one individuals were recruited.

Dietary zinc intake is inversely associated to metabolic syndrome in male but not in female urban adolescents.

Objective: To evaluate the relationship of copper and zinc dietary intakes with metabolic syndrome (MetS) in adolescents.

Methods: The sample consisted of 1,311 adolescents aged 11-16 years, and MetS definition by de Ferranti et al. was used.

Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women.

Objective: To evaluate the relationship between nutrients intake in the first trimester of pregnancy and blood levels of lead and cadmium during the first and third trimesters of gestation.

Methods: A total of 381 pregnant women were enrolled. Blood lead and cadmium were measured using electrothermal atomic absorption spectrometry, and dietary intake was assessed using 24-h recall questionnaire.

Adiposity markers and cardiovascular risk in urban Colombian adolescents: heterogeneity in association patterns.

Objective: The aim of this study was to evaluate the relationship of tricipital (TS), abdominal (AS), subscapular (SS), and suprailiac (SIS) skinfolds, Body Mass Index (BMI), and Waist Circumference (WC) with 1) variables related to cardiovascular risk (CVR) and 2) the clustering of cardiovascular risk factors (CVRF) - referenced pediatric cut-off points - in a multivariate analysis.

Materials/methods: The sample was 1672 adolescents. Glucose, lipid profile, blood pressure and anthropometric variables were measured.

Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.

Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these signals to regulation of β-cell mass are not completely understood. Recent findings indicate that mTOR pathway integrates signals from growth factors and nutrients with transcription, translation, cell size, cytoskeleton remodeling and mitochondrial metabolism.

Body iron stores as predictors of insulin resistance in apparently healthy urban Colombian men.

The aim of this study was to evaluate body iron stores as predictors of insulin resistance. We developed a cross-sectional study among 123 men, 25-64 years of age and determined fasting plasma glucose, insulin, serum ferritin, and C-reactive protein levels. A survey was performed to record personal antecedents and family history of non-transmissible chronic diseases.

Inverse correlation between serum calcium and copper levels in male urban Colombian preschool children: relationships with anthropometry and age.

Copper and calcium are essential for human growth and development. The present study was conducted to evaluate the relationship between calcium and copper levels, as well as their relationship to age and anthropometry in 180 preschool children ages 2-5 years old. Serum copper levels were inversely correlated with age (r = -0.

[Association of risk factors for non transmissible chronic diseases with insuline sensitivity, in young adults in the city of Cali, Colombia].

The prevalence of insulin resistance and risk factors for chronic diseases is not known in Colombia. The purpose of the study was of determine the association of insulin resistance and risk of chronic diseases in young, apparently healthy adults. By convenience, 97 subjects, mean age of 24 years were studied.

[Postprandial lipemia in Colombian young adults from different ethnic groups].

Postprandial lipemia has been associated with atherogenesis and other non infectious chronic diseases. A descriptive, non aleatory study of 51 healthy young adults (23.8 +/- 4 years) of different ethnic background was carried out to identify possible personal or life style factors associated with the response of plasma lipids after a mixed carbohydrate and lipid load.