Publications by authors named "Cecile Raverdy"
Article Synopsis
- * The trial included three groups: obese adolescents with and without vitamin D supplementation and a control group of normal-weight teens, finding high vitamin D insufficiency in the obese group compared to controls.
- * After 12 weeks, while vitamin D levels increased in both obese groups, improvements in intima-media thickness (IMT) were observed in the obese group receiving supplementation, although carotid compliance showed no significant change.
Background And Aim: Childhood obesity is associated with vitamin D (VD) deficiency and vascular dysfunction. Considering evidence indicates that VD may improve vascular function, this study, for the first time, assessed the effect of VD supplementation on microvascular reactivity in obese adolescents (OA).
Methods And Results: This randomized controlled trial included 26 OA, receiving fruit juice with (n = 13) or without VD (4000 IU/d; n = 13) over a 3-month lifestyle program, as well as 23 normal-weight adolescents (controls).
The optimal exercise modality for the improvement of health-related parameters and microvascular function in obese adolescents is not yet fully understood. Therefore, this study aimed to 1) compare the microvascular phenotype of obese and normal-weight adolescents; and 2) to determine the effects of a lifestyle intervention including three months of moderate continuous training (MCT) or high-intensity interval training (HIIT) on health-related parameters and microvascular function in 29 obese adolescents. Body composition, metabolic profile, aerobic fitness and cutaneous blood flow, measured using laser Doppler flowmetry at rest and during post-occlusive reactive hyperemia, were assessed prior to and following lifestyle intervention.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on identifying β-cell epitopes recognized by CD8(+) T cells in type 1 diabetes (T1D) patients, specifically those linked to the HLA-B7 molecule, which offers some protection against T1D.
- Using techniques like DNA immunization and predictive algorithms, researchers identified candidate epitopes from GAD and preproinsulin that were mainly recognized by new-onset T1D patients, distinguishing them from type 2 diabetes and healthy individuals.
- Findings indicate that HLA-B7-restricted epitopes exhibit unique characteristics, such as weak binding and stability compared to HLA-A2, and reveal different immune responses in T1D children versus adults, which may clarify the protective effects of