Publications by authors named "Cecile Ghander"
Objective: Fine needle aspiration (FNA) cytological analysis fails to confirm the benignity or malignancy of Bethesda III, IV and V thyroid nodules. Molecular tests performed on FNA samples have demonstrated interesting results in improving the diagnosis of these nodules. The aim of this study was to assess the performance of a large next-generation sequencing (NGS) panel in thyroid nodules with indeterminate cytology (Bethesda III, IV, V).
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- The study analyzed patients from 2017 to 2022, comparing postoperative serum calcium levels and PTH levels taken shortly after the surgery to create a management algorithm involving calcium and alfacalcidol for those with low intraoperative PTH levels.
- Results showed that using intraoperative PTH levels improved prediction of symptomatic hypocalcemia significantly, identifying 90% of cases, while only 58% could be predicted using postoperative serum calcium levels alone.
The current dogma is a life-long follow-up for patients treated for follicular-derived differentiated thyroid cancers (DTC). Our primary objective was to determine the time to recurrence in a series of DTC patients with an excellent response to therapy 6 months after total thyroidectomy and radioiodine therapy. The secondary objectives were to determine the time to suspicion of recurrence and to identify factors associated with recurrence.
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- Recent advancements suggest that using targeted therapies like BRAFV600E and MEK inhibitors (dabrafenib and trametinib) can be beneficial for patients with BRAF-mutated anaplastic thyroid carcinoma (ATC).
- A method called droplet digital PCR (ddPCR), conducted on fine-needle aspirate (FNA), provides fast and reliable detection of the BRAFV600E mutation, enabling quicker treatment initiation.
- In two cases with large, inoperable cervical masses, ddPCR results were obtained in under 24 hours, allowing for prompt treatment with dabrafenib and trametinib, potentially improving patient outcomes.
An 87-year-old woman was referred to our department for a 15 cm right-sided cervical tumor with bleeding and skin ulceration, developed on a 6 cm papillary thyroid carcinoma diagnosed two years earlier. Surprisingly, there were no other compressive symptoms. Unexpectedly, but successfully, total thyroidectomy and neck dissection were performed.
View Article and Find Full Text PDFIntroduction: Hyperthyroid patients who are unresponsive to medical treatment remain a challenging clinical problem.
Objective: The goal of our study was to evaluate the use of therapeutic plasma exchange (TPE) in hyperthyroid patients and their outcome after TPE.
Method: We retrospectively reviewed 22 patients who underwent TPE for refractory thyrotoxicosis in our institution: 13 with Graves' disease, 7 with amiodarone-induced thyrotoxicosis (AIT), 1 with toxic goiter, and 1 pregnant patient with familial nonautoimmune thyrotoxicosis.
To evaluate the effect of operator experience on the treatment outcomes of radiofrequency ablation (RFA) for benign thyroid nodules (BTN). Data from the 90 first RFA procedures of a single operator in treating benign thyroid nodules were prospectively collected and retrospectively analyzed. Patients were divided into 3 groups according to their chronological treatment rank: patients 1-30 (G1), 31-60 (G2) and 61-90 (G3).
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- - The study examines the health issues faced by HIV-infected transwomen compared to HIV-infected cisgender men, focusing on metabolic syndrome, thyroid, and adrenal functions.
- - Results showed that while the prevalence of metabolic syndrome was similar between the two groups, transwomen had significantly higher rates of subclinical hypothyroidism (12% vs. 3%) and adrenal insufficiency (20% vs. 8%).
- - The findings indicate that although hormonal consumption was common among transwomen, it did not affect antiretroviral drug effectiveness; however, regular assessment of thyroid and adrenal functions is recommended for this population.
Background: To evaluate FCH-PET/CT and parathyroid 4D-CT so as to guide surgery in patients with primary hyperparathyroidism (pHPT) and prior neck surgery.
Methods: Medical records of all patients referred for a FCH-PET/CT in our institution were systematically reviewed. Only patients with pHPT, a history of neck surgery (for pHPT or another reason) and an indication of reoperation were included.
Background: Papillary thyroid carcinomas (PTC) in the pT3 category constitute a heterogeneous group of tumors with a variable risk of recurrence. The objectives of this study were (i) to estimate disease-free survival (DFS) and identify prognostic factors associated with recurrence in a cohort of pT3 PTC, and (ii) to evaluate the concept of delayed risk stratification in a cohort of pT3 tumors.
Methods: A total of 560 patients with pT3 PTC, treated and followed at the authors' institution, were studied.
Background: Pheochromocytoma, a rare catecholamine-producing tumor, might provoke stress-induced Takotsubo-like cardiomyopathy and severe cardiogenic shock. Because venoarterial-extracorporeal membrane oxygenation (VA-ECMO) rescue of pheochromocytoma-induced refractory cardiogenic shock has rarely been reported, we reviewed our ICU patients' presentations and outcomes.
Methods: All pheochromocytoma-induced refractory cardiogenic shock cases managed with VA-ECMO (January 2007-March 2015) were prospectively included and reviewed.
Background: Hypertrophic osteoarthropathy (HOA) is a rare condition characterized by bone and joint pain and digital clubbing usually associated with bronchopulmonary diseases. Primary HOA is rare and the pathogenesis remains unclear.
Objectives: Cases of HOA as a paraneoplastic syndrome associated with thyroid carcinoma are very rare - only 2 cases have been described in the literature.