Publications by authors named "Cecile Cres"
Metagenomics is a technique for genome-wide profiling of microbiomes; this technique generates billions of DNA sequences called reads. Given the multiplication of metagenomic projects, computational tools are necessary to enable the efficient and accurate classification of metagenomic reads without needing to construct a reference database. The program DL-TODA presented here aims to classify metagenomic reads using a deep learning model trained on over 3000 bacterial species.
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- Trypanosoma brucei is a parasite that causes sleeping sickness in humans and nagana in animals, posing a significant health issue in sub-Saharan Africa, where effective treatments are limited.
- Current treatments are stage-dependent and often inadequate, especially in the critical meningoencephalitic stage, highlighting the need for new therapies and a better understanding of parasite immune evasion.
- This study finds that indolepyruvate, a compound excreted by T. brucei, plays a crucial role in reducing inflammation and aiding the parasite's survival by modulating immune responses, specifically by lowering levels of the pro-inflammatory cytokine IL-1β through effects on the transcription factor HIF-1α.