Publications by authors named "Cecile Collignon"
The issue of assessing the effectiveness of health technologies (drugs, devices, etc.) through observational studies is becoming increasingly important as registration and market access agencies consider them in their evaluation process. In this context, observational studies must be able to provide real demonstrations of a level of reliability comparable to those produced by the conventional randomized controlled trial (RCT) approach.
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- - The significance of real-world data (RWD) in health technology assessments is increasing, as advancements in connected devices and data collection methods allow for better insights into treatment effects, potentially surpassing traditional clinical trial data in relevance.
- - A round table of experts aimed to clarify the current role of RWD by identifying its main purposes, evaluation timing, and the stakeholders involved in RWD studies.
- - The discussion concluded with six recommendations to enhance the application of RWD in health technology assessment and decision-making processes.
Early market access of health products is associated with a larger number of requests for information by the health authorities. Compared with these expectations, the growing expansion of health databases represents an opportunity for responding to questions raised by the authorities. The computerised nature of the health system provides numerous sources of data, and first and foremost medical/administrative databases such as the French National Inter-Scheme Health Insurance Information System (SNIIRAM) database.
View Article and Find Full Text PDFBackground And Purpose: A substantial part of ischemic strokes is attributed to atrial fibrillation (AF). We hypothesized that patients with ischemic stroke without prior diagnosed AF were at higher risk of having a subsequent diagnosis of AF, and this was associated with multiple risk factors.
Methods: This French longitudinal cohort study was based on the national database covering hospital care from 2008 to 2012 for the entire population.
Objective: To compare pharmacokinetics and clearances of creatinine and iohexol as estimates of glomerular filtration rate (GFR) in dogs with various degrees of renal function.
Animals: 50 Great Anglo-Francais Tricolor Hounds with various degrees of renal function.
Procedures: Boluses of iohexol (40 mg/kg) and creatinine (647 mg/kg) were injected IV.