Properties of silorane-based dental resins and composites containing a stress-reducing monomer.

Objective: To evaluate properties of silorane-based resins and composites containing a stress reducing monomer.

Methods: Resin mixtures and composites were formulated containing (a) a developmental stress reducing monomer [TOSU; Midwest Research Institute]; (b) Sil-Mix (3M-ESPE); (c) photo cationic initiator system. Standard BISGMA/TEGDMA resin (B/T) and composite (Filtek Z250) were used as controls.

Quantum mechanical structure-activity relationship analyses for skin sensitization.

Allergic contact dermatitis (ACD) results in inflammation of the skin due to sensitization of the immunologic system to a particular substance. The sensitization process is limited by the compound's ability to both permeate and react with proteins in the integumentary system. Currently, only in vivo animal tests such as the local lymph node assay (LLNA) are recognized by regulatory authorities for risk assessment of ACD.

An application of the QM-QSAR method to predict and rationalize lipophilicity of simple monomers.

Objectives: The goal of this study is to develop a model used to predict octanol/water partition coefficients (log P(o/w)) values for a variety of potential dental materials. In this way, a primary consideration for potential toxicity and a rough estimate of solubility in various environments can be obtained.

Method: The AM1 semiempirical quantum mechanical method (in AMPAC) was used to compute chemical data for all compounds in the study.

Photopolymerization of developmental monomers for dental cationically initiated matrix resins.

Objectives: The objectives were to investigate the structure and selected physical properties of products resulting from the photopolymerization of a binary mixture containing an aliphatic dioxirane, 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexane carboxylate (ECHM-ECHC) and a potential expanding monomer, 3,9-bis(oxiranylcyclohexylmethyl)-1,5,7,11-tetraoxaspiro[5.5]undecane (BOCHM-TOSU).

Methods: Reaction mixtures were irradiated with a dental curing lamp at room temperature.

In vitro mutagenicity and metabolism of the cycloaliphatic epoxy Cyracure UVR 6105.

Cyracure UVR 6105 is a cycloaliphatic epoxy monomer and has both carboxylate and epoxy groups, with the potential for rapid polymerization. It is widely used in industry for the preparation of inks, resins, coatings, and was proposed for incorporation into dental composites. The objective of this study was to determine the mutagenic potential of this chemical related to its metabolite products.

In vitro effect of light-cure dental adhesive on IL-6 release from LPS-stimulated and unstimulated macrophages.

The objective of this study was to measure IL-6 release from LPS-stimulated and -unstimulated macrophages exposed to extracts from fresh and aged Scotchbond Multipurpose Plus adhesive disks (5 mm in diameter by 2 mm in thickness) light cured for 10, 20, or 40 s. One set of disks was aged for 16 weeks at 4 degrees C. Extracts were prepared by incubating three disks in 1 mL of serum-free culture medium for 72 h at 37 degrees C.