Acute glycemic changes in brain and subcutaneous tissue measured by continuous glucose monitoring system in hereditary hypertriglyceridemic rat.

Parallel glucose measurements in blood and other different tissues give us knowledge about dynamics of glycemia changes, which depend on vascularization, distribution space and local utilization by tissues. Such information is important for the understanding of glucose homeostasis and regulation. The aim of our study was to determine the time-lag between blood, brain, and adipose tissue during rapid glucose changes in a male hHTG rat (n=15).

[Metabolic syndrome in patients with diabetes mellitus type 1, prevalence, impact on morbidity and mortality].

Unlabelled: Aim of this retrospective observational study was to determine the prevalence of metabolic syndrome (MS) in patients with diabetes mellitus type 1 (DM1Z) at baseline (in 2003) and find the parameters that determine the difference between group with (MS+) and without MS (MS-). Did the presence of MS affect morbidity and mortality in the subsequent 10 years?

Methods: 278 patients were enrolled to the study with age average 39 ± 13 years with medical history of diabetes 15.9 ± 9 years.

The influence of cardiovascular autonomic neuropathy on mortality in type 1 diabetic patients; 10-year follow-up.

Aim: The aim of our retrospective study was to answer the question if the presence of cardiovascular autonomic neuropathy (CAN) affects mortality in type 1 diabetic patients during a 10-year follow-up.

Methods: Patients with type 1 diabetes mellitus examined for CAN in 2003 were enrolled in this retrospective study. A total of 278 patients were included and divided into two groups according to the presence or absence of CAN (111 CAN+, 167 CAN-).

Monogenic glucokinase diabetes and pregnancy: a case study.

It is estimated that up to 3 % of patients with gestational diabetes have glucokinase diabetes, termed also maturity-onset diabetes of the young type 2. The disorder has autosomal dominant inheritance. There is a 50 % risk of transmission of the gene to next generation.

[Has the pregnancy outcome of women with pregestational diabetes mellitus improved in ten years?].

Introduction: In spite of progress in medicine, studies from a number of countries indicate steadily increased risk of perinatal morbidity and mortality in the offspring of diabetic mothers. No data regarding the pregnancy outcome in women with diabetes mellitus type 1 and 2 (pregestational DM) have been published in the Czech Republic. The aim of the study was to evaluate the pregnancy course of women with pregestational DM and outcome of their offspring and to assess whether it has improved in ten years.

[Celiac disease in adult patients with type 1 diabetes mellitus].

Objective: To assess the prevalence of celiac disease in adult patients with type 1 diabetes mellitus (T1DM). Influence the new started treatment of celiac disease on glycemic control and body mass index (BMI) of the patients. Prevail the anti-transglutaminase antibody (atTG) positivity one year after commencement of the therapy.

Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers.

Aim: To examine skin perfusion in dependency on insulinemia in healthy subjects.

Methods: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by the ethical committee.

[Does physical activity produce clinically significant changes during discontinuation of insulin pump in type 1 diabetic patients?].

Introduction: Discontinuation of insulin pump treatment (CSII) before, during and after physical activity is a common practice among a number of patients. The aim of the study was to evaluate the course of insulinemia during a 3- hour insulin pump suspension and after consecutive insulin bolus administration, and additionally, to assess the effect of physical activity (mid intensity aerobic exercise).

Patient And Methods: We enrolled 12 patients with diabetes mellitus type 1 in the study (men, mean age 33.

Differences in skin microcirculation on the upper and lower extremities in patients with diabetes mellitus: relationship of diabetic neuropathy and skin microcirculation.

Introduction: During recent years, the role of microcirculation has received increasing attention especially for its potential pathogenic role in the development of diabetes complications, particularly diabetic foot syndrome. The aim of this study was to evaluate the differences in the skin microcirculatory reactivity on the upper and lower extremities (UE and LE, respectively) in the patient with type 2 diabetes mellitus (T2DM). We also evaluated the changes in the skin microcirculation independently of the individual test for peripheral diabetic neuropathy (DN) diagnosis (Semmes-Weinstein monofilaments, Bio-Thesiometer [Bio-Medical Instrument Co.

[Spondylodiscitis and epidural empyema as a complication of diabetic foot].

Unlabelled: Spinal column infection (vertebral osteomyelitis, discitis, epidural empyema/ abscess) is a rare condition, albeit its incidence has been increasing in recent years. Staphylococcus aureus is the most frequent pathogen. The routes of infection are predominantly hematogenous.

[Unusual cause of foot defect in patient with diabetes mellitus].

Foot complications are one of the most serious and costly complications of diabetes mellitus. Amputation of a part of a lower extremity is usually preceded by a foot ulcer. There have been also other not so typical causes of foot defect.

Comparison of a low-glycemic index vs standard diabetic diet.

Aim: There is insufficient evidence for the efficacy of a low-glycemic index (GI) diet in the management of diabetes. The goal of this study was to measure the effect of a low GI versus a standard diabetic diet in adults with diabetes type 2.

Methods: This was an open label, randomized, crossover study.

[Long-term evaluation of patients with type 1 diabetes mellitus treated with insulin glargine].

Aims Of The Study: To evaluate long-term effects of treatment with insulin analogue glargine in patients with type 1 diabetes mellitus and to follow up their further course of life.

Patient Sample And Methodology: Retrospective evaluation of 114 patients who, from September 2004, had their basal insulin changed from NPH insulin to insulin glargine. Treatment was changed again in patients in whom a year-long treatment with insulin glargine did not bring improvement in diabetes control.

Analysis of continuous patient data from the Czech National Register of patients with type 1 and type 2 diabetes using insulin pump therapy.

Aim: Patient data from the Czech National Register of patients treated with Continuous Subcutaneous Insulin Infusion (CSII) were evaluated to compare treatment indication, efficacy and safety with specific regard to the type of diabetes (T1 vs. T2).

Methods: Evaluation was done on complete data sets of at least 3 years from patients with either T1 diabetes (n=730, 93.

The influence of insulin pump treatment on metabolic syndrome parameters in type 2 diabetes mellitus.

Introduction: The aim of our study was to evaluate the influence of long-term insulin pump treatment (CSII) on the parameters of metabolic syndrome in insulin-resistant patients with poorly controlled type 2 diabetes mellitus.

Patients And Methods: Thirteen obese (BMI>30) patients (8 women, 5 men), average age 58.8+/-9.

Effect of mild increase of physical activity on microvasculary reactivity in obese subjects with diabetes mellitus type 2.

Unlabelled: Microangiopathy, well known in diabetic patients as a cause of late complications, develops mainly due to chronic exposition to elevated glucose and triglyceride level. Physical training acts as a protective factor even if no changes in metabolic parameters are observed. It's supposed, that lifestyle modification leads to the improvement of endothelial dysfunction and microvasculary reactivity, in healthy subjects it has already been proven experimentally.

Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with type 1 diabetes.

Aim: Cardiovascular autonomic neuropathy (CAN) increases mortality of patients with type 1 diabetes (Type 1 DM). We set out to find out whether the presence of CAN in asymptomatic, normotensive Type 1 DM affects endothelial function (marker of atherogenesis) and left ventricle function (marker of cardiomyopathy).

Methods: Twenty-one Type 1 DM with CAN (Group A) and 35 Type 1 DM without CAN (Group B) were enrolled in the study.

[Glycated haemoglobin--is it its exclusive position in diabetology under threat?].

Hyperglycaemia is the common characteristic for diabetes patients. Prolonged hyperglycaemia due to absolute or relative lack of insulin is the cause of microangiopathy. Glucose reacts with both blood vessel wall proteins and plasmatic proteins and erythrocyte haemoglobin.

[Clinical experience in treatment with the long-term insulin analogue glargin in a diabetes centre].

Objective: To assess the experience obtained by a diabetes centre in the treatment of patients with type 1 diabetes with the long-term insulin analogue glargin.

Patient Sample And Method: 136 patients with type 1 diabetes mellitus (DM) were evaluated on a retrospective basis for the period from March 2004 to march 2005. We monitored HbA(1c) before the treatment with glargin, after 3 months, again after 6 months, and finally after 1 year of therapy.

Could we predict asymptomatic cardiovascular autonomic neuropathy in type 1 diabetic patients attending out-patients clinics?

Background And Aims: Diabetic cardiovascular autonomic neuropathy (CAN) is associated with increased morbidity and mortality. This complication may be asymptomatic for a long time. The aim of this study was to assess the prevalence, severity and predictors of asymptomatic CAN in patients with type 1 diabetes mellitus (DM1).

[Transcutaneous oxygen tension in hyperbaric condition as a predictor of ischaemia in non-healing diabetic foot ulcers].

Unlabelled: The aim of the study was to evaluate the contribution of basal and modify transcutaneous oxygen tension measurement (TcpO2) to diagnosis of ischaemia and indication of angiography in non-healing diabetes foot ulcers:

Method: 69 patients with non-healing diabetic ulcers localised on 76 legs underwent angiography (DSA) and basal and modify TcpO2 measurement after 100 % O2 exposition under normo- and hyperbaric conditions. CHARACTERISTIC OF PATIENTS: mean age 66 years (42 81), diabetes duration 14.3 years (1 - 36), glycated hemoglobin 7.

[Short-term and long-term effect of metformin in type 1 diabetics].

Unlabelled: The objective of the investigation was to evaluate the effect of metformin added to the usual insulin treatment on insulin resistance, on the dose of substituted insulin and on the compensation of type 1 diabetes.

Method: The first part of the study lasted 3 months, it was an open prospective study. The group was formed by 22 type 1 diabetics, average age 38.

[Economic aspects of the diabetic foot syndrome].

Unlabelled: The diabetic foot is one of the most expensive complications of diabetes mellitus.

Aims: To determine the direct costs of both inpatient and outpatient care of diabetic foot provided in Diabetic Centre University Hospital in Plzen.

Methods: 42 patients with diabetic ulcers (45% neuropathic, 26% ischaemic and 29% mixed) who have attended the podiatric surgery from January to June 2000 were randomly selected.

[Autonomic neuropathy in diabetics, treatment possibilities].

Diabetic neuropathy is a chronic complication of diabetes. It involves non-inflammatory damage of the function and structure of peripheral nerves by metabolic vascular pathogenic processes. In case of affection of vegetative nerves (small non-myelinated C fibres) autonomic neuropathy develops.