Towards an optimal design of a functionally graded porous uncemented acetabular component using genetic algorithm.

Generation of polyethylene wear debris and peri‑prosthetic bone resorption have been identified as potential causes of acetabular component loosening in Total Hip Arthroplasty. This study was aimed at optimization of a functionally graded porous acetabular component to minimize peri‑prosthetic bone resorption and polyethylene liner wear. Porosity levels (porosity values at acetabular rim, and dome) and functional gradation exponents (radial and polar) were considered as the design parameters.

Mechanobiochemical bone remodelling around an uncemented acetabular component: influence of bone orthotropy.

Mechanical loosening of an implant is often caused by bone resorption, owing to stress/strain shielding. Adaptive bone remodelling elucidates the response of bone tissue to alterations in mechanical and biochemical environments. This study aims to propose a novel framework of bone remodelling based on the combined effects of bone orthotropy and mechanobiochemical stimulus.

Biomechanical analysis of functionally graded porous interbody cage for lumbar spinal fusion.

Functionally graded porous (FGP) interbody cage might offer a trade-off between porosity-based reduction of stiffness and mechanical properties. Using finite element models of intact and implanted lumbar functional spinal unit (FSU), the study investigated the quantitative deviations in load transfer and adaptive changes in bone density distributions around FGP interbody cages. The cage had three graded porosities: FGP-A, -B, and -C corresponded to a maximum porosity levels of 48%, 65% and 78%, respectively.

Design of a functionally graded porous uncemented acetabular component: Influence of polar gradation.

The functionally graded porous metal-backed (FGPMB) acetabular component has the potential to minimize strain-shielding induced bone resorption, caused by stiffness mismatch of implant and host bone. This study is aimed at a novel design of FGPMB acetabular component, which is based on numerical investigations of the mechanical behavior of acetabular components with regard to common failure scenarios, considering various daily activities and implant-bone interface conditions. Both radial and polar functional gradations were implemented, and the effects of the polar gradation exponent on the failure criteria were evaluated.

Numerical Evaluations of an Uncemented Acetabular Component in Total Hip Arthroplasty: Effects of Loading and Interface Conditions.

Using finite element (FE) models of intact and implanted hemipelvises, the study aimed to investigate the influences of musculoskeletal loading and implant-bone interface conditions on preclinical analysis of an uncemented acetabular component after total hip arthroplasty (THA). A new musculoskeletal loading dataset, corresponding to daily activities of sitting up-down, stairs up-down and normal walking, for a pelvic bone was generated based on previously validated Gait2392 model. Three implant-bone interface conditions, fully bonded and debonded having two rim press-fits (1 mm and 2 mm), were analyzed.

Bone Remodeling Around Solid and Porous Interbody Cages in the Lumbar Spine.

Spinal fusion is an effective surgical treatment for intervertebral disk degeneration. However, the consequences of implantation with interbody cages on load transfer and bone remodeling in the vertebral bodies have scarcely been investigated. Using detailed three-dimensional models of an intact and implanted lumbar spine and the strain energy density based bone remodeling algorithm, this study aimed to investigate the evolutionary changes in distribution of bone density (ρ) around porous and solid interbody cages.